Evidence map›Paper›PMID 41163952›Full record

ArticleInternational journal of nanomedicine2025

ROS/Glucose-Dissociable EGCG-Coated Oxygen-Supplying Nanocomposite Hydrogel for Diabetic Wound Therapy.

Shiyu Sun, Rongxue Zhu, Junneng Du, Jin Lin, Yuying Li, Qian Jiang, Tianzong Huang, Enping Huang, Yingping Jiang, Xiaoya Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shiyu Sun *Department of Rehabilitation Medicine, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, 510310, People's Republic of China.
Rongxue Zhu *Department of Rehabilitation Medicine, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, 510310, People's Republic of China.
Junneng DuDepartment of Rehabilitation Medicine, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, 510310, People's Republic of China.
Jin LinDepartment of Rehabilitation Medicine, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, 510310, People's Republic of China.
Yuying LiDepartment of Rehabilitation Medicine, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, 510310, People's Republic of China.
Qian JiangDepartment of Rehabilitation Medicine, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, 510310, People's Republic of China.
Tianzong HuangDepartment of Rehabilitation Medicine, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, 510310, People's Republic of China.
Enping HuangGuangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, 510515, People's Republic of China.
Yingping JiangDepartment of Rehabilitation Medicine, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, 510310, People's Republic of China.
Xiaoya ZhangDepartment of Rehabilitation Medicine, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, Guangdong, 510310, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: In diabetic wounds, a detrimental and persistent inflammatory environment characterized by impaired angiogenesis and concomitant hypoxia severely impedes wound healing. This study utilized phenylboronic acid-grafted quaternized chitosan (QCS-PBA) to encapsulate calcium peroxide (CaO Methods: In this study, QP@Ca-E loaded with CaO Results: The GP-GL@Ca-E oxygen-supplying multifunctional hydrogel provides an effective physical barrier for irregular wounds. Moreover, the GP-GL@Ca-E hydrogel responds to ROS and glucose in the wound microenvironment to enable sustained EGCG release. EGCG not only exhibits excellent antibacterial, anti-inflammatory, and antioxidant properties but also promotes angiogenesis. Subsequently, the exposed CaO Conclusion: The results indicate the successful preparation of a multifunctional oxygen-producing hydrogel, which exhibits remarkable antibacterial properties and ROS scavenging capability. This hydrogel can effectively suppress inflammatory responses, promote macrophage polarization toward the M2 phenotype, and enhance angiogenesis, thereby creating a favorable immune microenvironment for skin regeneration. These characteristics collectively demonstrate its promising potential for application in diabetic wound healing.

Indexed as

CatechinHydrogelsNanocompositesWound HealingAnimalsAnti-Bacterial AgentsAntioxidantsBoronic AcidsChitosanDiabetes Mellitus, ExperimentalGelatinGlucoseHumansMaleMiceOxygenAnti-Bacterial AgentsAntioxidantsbenzeneboronic acidBoronic Acidscalcium peroxideCatechinChitosanepigallocatechin gallateGelatinGlucoseHydrogelsOxygenPeroxidesReactive Oxygen Speciesdiabetic wound therapyEGCG-coatedoxygen productionROS/glucose-dissociable

Identifiers

PMID41163952
PMCPMC12560043

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.