ArticleHealth science reports2025
Bone Mineral Accrual From Adolescence Into Young Adulthood and Peak Bone Mass: A Longitudinal Cohort Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Fremanezumab for episodic migraine in children and adolescents: the evolving landscape of CGRP-targeted therapies.Translational pediatrics · 2026Article
- Toe Grasp Strength and Its Association with Muscle Mass and Calcaneal Bone Status in Young Adults: A Cross-Sectional Study.Journal of musculoskeletal & neuronal interactions · 2026Article
- [Trends in burden of osteoporosis in China from 1990 to 2023 and analysis of epidemiological factors].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Unveiling the wealth-bone connection: How socioeconomic status influences trabecular bone health.PloS one · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Understanding bone mass accumulation patterns and factors influencing them during growth is important for preventing osteoporosis later in life. This study investigated longitudinal changes in bone mineral content (BMC), bone mineral density (BMD), and bone mineral apparent density (BMAD) during growth, with the aim of estimating the age at which peak bone mass (PBM) is achieved in males and females. It also examined the effects of puberty, age, body mass index (BMI), sex, socioeconomic status (SES), and habitual exercise on these bone parameters during adolescence and early adulthood. Methods: This retrospective cohort study included 159 participants. Bone densitometry was performed using dual-energy x-ray absorptiometry (DXA) during two assessments. Anthropometric measurements were obtained, and demographic data, pubertal stage, medical history, SES, and exercise habits were collected through a structured questionnaire administered by a physician. Results: Rates of change in total body BMC (TBBMC) and BMD (TBBMD) decreased with advancing age and pubertal stage, with the highest rates observed at ages 9-11 and Tanner stage 1. Across all ages up to 18 years, males showed significantly higher rates than females. Peak TBBMC and TBBMD occurred at 25.7 and 26.2 years in males, and 24.8 and 24.0 years in females. After adjusting for bone size, BMAD peaks at the femoral neck and lumbar spine were 21.2 and 23.8 years in males, and 24.8 and 24.1 years in females. Linear mixed model analysis indicated that older age, higher BMI, male sex, higher SES (significant for BMD), and greater physical activity positively influenced TBBMC and TBBMD until peak values were reached. Conclusion: Bone accumulation was greater in adolescence than in early adulthood. PBM was generally reached in the mid-third decade, with females attaining it earlier. Age, sex, BMI, SES, and exercise positively influenced TBBMC and TBBMD during adolescence and early adulthood.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.