ArticleFrontiers in pediatrics2025
Microvascular changes in children with MIS-C: a monocentric exploratory study using comparative nailfold capillaroscopy.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Nailfold Videocapillaroscopy in Pediatric Rheumatology: Established Roles, Emerging Applications, and Future Perspectives.Balkan medical journal · 2026Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Multisystem Inflammatory Syndrome in Children (MIS-C) is a severe hyperinflammatory condition that arises after SARS-CoV-2 infection and may lead to endothelial dysfunction and microvascular damage. Despite increasing knowledge on systemic manifestations, microcirculatory involvement in MIS-C remains underexplored. Objective: To evaluate nailfold capillaroscopy (NFC) findings in children diagnosed with MIS-C and compare them with age- and sex-matched healthy controls, thereby assessing subclinical microvascular alterations associated with MIS-C. Methods: In this cross-sectional study, 25 MIS-C patients meeting CDC criteria and 29 age-/sex-matched controls underwent standardized NFC at 200× magnification by a blinded examiner. Eight fingers (excluding thumbs) were imaged. Morphological parameters (tortuosity, crossing, dilatation, neoangiogenesis, etc.) and quantitative measures (capillary density, lengths, widths, intercapillary distance) were recorded. Tortuosity and crossing were scored semi-quantitatively (0: absent; 1: < 50% affected; 2: > 50% affected). Between-group comparisons used Mann-Whitney U and Chi-square/Fisher tests ( Results: MIS-C patients had higher rates of tortuosity (92.0% vs. 62.1%, Conclusion: Nailfold capillaroscopy revealed notable microvascular alterations in children with MIS-C, including increased tortuosity, dilated capillaries, and disorganization. These findings suggest that NFC may serve as a useful non-invasive tool for detecting endothelial dysfunction and early microvascular involvement in MIS-C. Importantly, given the current rarity of MIS-C cases in the post-pandemic era, this study provides a unique and timely contribution, offering one of the few systematic evaluations of microvascular alterations in pediatric MIS-C and establishing a valuable reference point for future comparative research in pediatric vasculopathies.
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