ArticleFrontiers in pediatrics2025
Comparative analysis of CRP and PCT as biomarkers for early diagnosis of pediatric septic arthritis: superior performance of CRP.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- How Should Bacteriological Sampling Be Stratified in Paediatric Septic Arthritis? A Narrative Review with a Proposed Risk-Stratified Framework.Antibiotics (Basel, Switzerland) · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Septic arthritis is a severe pediatric infection that affects joint health and requires early diagnosis to prevent complications. Traditional methods have limitations, and although serum PCT shows promise as a diagnostic marker, its efficacy remains controversial, warranting further studies. Objective: To investigate the value of C-reactive protein (CRP) and procalcitonin (PCT) in the early diagnosis of septic arthritis (SA) in pediatric patients and to compare their diagnostic efficiencies. Methods: This investigation utilized a retrospective cohort methodology to ascertain and compare serum procalcitonin (PCT) and C-reactive protein (CRP) concentrations among a pediatric population comprising 29 individuals diagnosed with septic arthritis and 25 with non-septic arthritis (NSA), all of whom were admitted to our institutional facility over a three-year period from 2019 to 2021. Results: CRP levels (>10 mg/L) were significantly higher in the septic arthritis group than in the non-septic group (26/29 vs. 3/25, Conclusion: Our findings substantiate the substantial superiority of CRP for the early detection and preliminary alert of pediatric septic arthritis. However, due to the small sample size, its significant advantage over procalcitonin (PCT) requires confirmation in larger studies.
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