ArticleGastroenterology research and practice2025
The Risk Factor Analysis of Gallbladder Gangrene in Acute Acalculous Cholecystitis: A Single-Center Retrospective Study.
Article in Gastroenterology research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Diagnostic and Prognostic Value of AISI, SII, and SIRI in Predicting Gangrenous Evolution of Acute Lithiasic Cholecystitis.Diagnostics (Basel, Switzerland) · 2026Article
- Artificial intelligence in gangrenous cholecystitis: advances in risk factor identification and preoperative prediction-a scoping review.Frontiers in surgery · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This research was performed to determine the risk factors for gallbladder gangrene in acute acalculous cholecystitis patients and to assess the predictive ability of inflammatory markers. Methods: The study included 226 acute acalculous cholecystitis patients who underwent laparoscopic cholecystectomy within 72 h of onset. The receiver operating characteristic curves were employed to determine the optimal cut-off, specificity, and sensitivity of inflammatory markers in predicting gangrenous cholecystitis. Logistic regression analysis was conducted to ascertain the independent risk factors associated with gallbladder gangrene. Results: The incidence rate of gallbladder gangrene in acute acalculous cholecystitis was 45.1% (102/226). Compared with other inflammatory markers, the systemic immune-inflammation index (SII) demonstrated superior predictive validity (vs. CRP, Conclusion: This study found that platelet, PCT, SII, D-dimer, CA19-9, gallbladder enlargement, and gallbladder effusion were independent risk factors for gallbladder gangrene in acute acalculous cholecystitis. SII could serve as a novel, straightforward, and potent predictive indicator for gallbladder gangrene in acute acalculous cholecystitis.
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