ArticleAnnals of thoracic surgery short reports2025
Impact of Collateral Vessels on Fontan Circulation: 0- to 1-Dimensional Fontan Circulation Model and Concept of Oxygen Supply and Consumption.
Article in Annals of thoracic surgery short reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Patients with single ventricle often undergo the Fontan operation to alleviate cyanosis and reduce ventricle volume load. However, long-term outcomes are limited by complications and hemodynamic issues, including collateral vessels, leading to cyanosis and heart failure. Studies have demonstrated considerable blood flow through these collateral vessels; however, their hemodynamic impact on Fontan circulation remains inadequately explained from a theoretical perspective. This study aims to clarify the effects of dobutamine and vasodilators on Fontan circulation in the presence of aortopulmonary collaterals (APCs) and venovenous collaterals (VVCs). Methods: A Fontan hemodynamic model incorporating VVC and APC was created. Scenarios were simulated by adjusting dobutamine dosage and oxygen delivery/consumption, predicting arterial and central venous oxygen saturations. Cardiac function was evaluated based on cardiac output, arterial elastance, ejection fraction, and stroke work to pressure-volume ratio. Results: Fontan circulations with VVC and APC had lower arterial and venous oxygen saturations (92% and 54%, respectively) compared with those without collaterals (96% and 62%, respectively). Decreased arterial elastance and increased stroke work to pressure-volume ratio indicated poor tissue perfusion. High pulmonary resistance decreased oxygen saturations and systemic blood flow, regardless of collaterals. Dobutamine (10 μg/kg/min) raised venous oxygen from 53% to 58%, respectively, in the presence of VVC and APC, but decreased arterial oxygen from 92% to 88%, respectively. Conclusions: The results align with clinical findings, suggesting pulmonary vasodilators may improve oxygenation and perfusion in Fontan patients with collaterals. However, dobutamine effects are limited. Validation with actual patient data is needed to enhance model accuracy.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.