Evidence map›Paper›PMID 41163841›Full record

ArticleRSC advances2025

β-Branching in the biosynthesis of bongkrekic acid: a complex affair.

Megan E M Hiseman, Annabel P Phillips, Ciprian Chiriac, Liam J Smith, John Crosby, Christopher Williams, Christine L Willis, Ashley J Winter, Matthew P Crump

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Megan E M HisemanSchool of Chemistry, University of Bristol Bristol BS8 1TS UK ash.winter@bristol.ac.uk matt.crump@bristol.ac.uk.ORCID https://orcid.org/0009-0009-6273-4863
Annabel P PhillipsSchool of Chemistry, University of Bristol Bristol BS8 1TS UK ash.winter@bristol.ac.uk matt.crump@bristol.ac.uk.ORCID https://orcid.org/0000-0002-6290-3809
Ciprian ChiriacSchool of Chemistry, University of Bristol Bristol BS8 1TS UK ash.winter@bristol.ac.uk matt.crump@bristol.ac.uk.
Liam J SmithSchool of Chemistry, University of Bristol Bristol BS8 1TS UK ash.winter@bristol.ac.uk matt.crump@bristol.ac.uk.ORCID https://orcid.org/0009-0002-6296-2910
John CrosbySchool of Chemistry, University of Bristol Bristol BS8 1TS UK ash.winter@bristol.ac.uk matt.crump@bristol.ac.uk.ORCID https://orcid.org/0000-0002-8389-7102
Christopher WilliamsSchool of Chemistry, University of Bristol Bristol BS8 1TS UK ash.winter@bristol.ac.uk matt.crump@bristol.ac.uk.ORCID https://orcid.org/0000-0001-5806-9842
Christine L WillisSchool of Chemistry, University of Bristol Bristol BS8 1TS UK ash.winter@bristol.ac.uk matt.crump@bristol.ac.uk.ORCID https://orcid.org/0000-0002-3919-3642
Ashley J WinterSchool of Chemistry, University of Bristol Bristol BS8 1TS UK ash.winter@bristol.ac.uk matt.crump@bristol.ac.uk.ORCID https://orcid.org/0000-0003-3684-9383
Matthew P CrumpSchool of Chemistry, University of Bristol Bristol BS8 1TS UK ash.winter@bristol.ac.uk matt.crump@bristol.ac.uk.ORCID https://orcid.org/0000-0002-7868-5818

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bongkrekic acid is a potent respiratory toxin which inhibits the mitochondrial ATP/ADP carrier protein. The polyketide synthase that biosynthesises bongkrekic acid recruits a discrete cassette of β-branching enzymes (BonF-BonI) to install two distinct β-branches: an

Identifiers

PMID41163841
PMCPMC12560621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.