ArticleJournal of medical physics
Optimizing CyberKnife Stereotactic Radiosurgery for Motor-eloquent Brain Arteriovenous Malformations Using Diffusion Tensor Imaging-based Tractography.
Article in Journal of medical physics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Neural pathway-guided radiosurgery: A systematic review and meta-analysis of diffusion tensor imaging applications in stereotactic radiosurgery.Neurosurgical review · 2026Pooled it
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Management of brain arteriovenous malformations (bAVMs) close to motor areas with stereotactic radiosurgery (SRS) is challenging due to the risk of radiation-related morbidity. This risk stems from the increased radiosensitivity of the surrounding white matter (WM), which is crucial for preserving motor function. Purpose: This study aimed to investigate the application of diffusion tensor imaging (DTI)-based magnetic resonance (MR) tractography SRS planning for bAVMs, with a focus on sparing WM tracts during CyberKnife treatment. The goal was to minimize radiation exposure to motor-relevant WM tracts, thereby reducing the risk of posttreatment motor deficits and improving patient outcomes. Materials and Methods: The DTI-based reconstructions of WM tracts from 22 patients with motor-eloquent bAVMs were integrated into the CyberKnife planning system and co-registered with treatment planning images. The WM tracts, located within normal tissue and not overlapping with the target volume of the bAVMs, were delineated as dose constrain volumes. Initial treatment plans, excluding WM tracts, were compared with WM tracts constraint plans that incorporated these tracts to assess and compare radiation doses delivered to WM structures in both plans. Results: With WM tracts constraint, maximum dose of WM tracts can be reduced by 17.68% on average (range 13.61%-33.29%), thus from 20.81 Gy to 17.13 Gy ( Conclusion: Integrating DTI-based MR tractography into CyberKnife SRS for motor-eloquent bAVMs was feasible and preserves critical motor tracts without compromising radiation therapy goals.
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