ArticleJournal of medical physics
Preclinical Lutetium-177 Intracellular Dosimetry of Target Cancers in Radionuclide Therapy.
Article in Journal of medical physics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
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Abstract
Purpose: This study investigates the preclinical dosimetry of Lutetium-177 in targeted radionuclide therapy for cancer treatment, focusing on the radiopharmaceutical [ Materials and Methods: Subcutaneous HT-29 xenografts were established in nu/nu mice and administered [ Results: Using HT-29 tumor cell xenografts in nude mice, the research evaluated the absorbed doses in tumor cell nuclei, considering both self-radiation and cross-radiation from neighboring cells. A mathematical model of a spherical cell cluster (radius = 280 µm) was developed to simulate dose distribution, accounting for beta-particle range and linear energy transfer. Conclusions: Results indicate that the absorbed dose varies with cell position within the cluster, ranging from 3.2 Gy at the surface to 8.4 Gy at the center. The study also calculates cell survival probabilities using a linear-quadratic model, revealing a relative biological effectiveness (RBE) of up to 2 for [
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