Evidence map›Paper›PMID 41163734›Full record

ArticleNeurosurgery practice2025

Efficacy and Safety of CyberKnife Stereotactic Radiosurgery for Occipital Condyle Metastasis.

David J Park, Harini Voruganti, Shreyas Annagiri, Elaheh Shaghaghian, Yusuke S Hori, Amit R Persad, Kelly H Yoo, Deyaaldeen Abu-Reesh, Fred C Lam, Armine Tayag and 11 more

Abstract read
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In one paragraph

Article in Neurosurgery practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

David J ParkDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.ORCID https://orcid.org/0000-0002-9858-2592
Harini VorugantiDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Shreyas AnnagiriDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Elaheh ShaghaghianDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Yusuke S HoriDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Amit R PersadDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Kelly H YooDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Deyaaldeen Abu-ReeshDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Fred C LamDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Armine TayagDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Louisa UstrzynskiDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Sara C EmrichDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Summer S HanDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Xuejun GuDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.
John ByunDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.
Elham RahimyDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.
Erqi L PollomDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.
Scott G SoltysDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.
Melanie Hayden GephartDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Gordon LiDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.
Steven D ChangDepartment of Neurosurgery, Stanford University School of Medicine, Stanford, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesOccipital condyle metastasis (OCM) is a rare condition characterized by severe occipital pain and neurological symptoms due to lower cranial nerve (CN) deficits, stemming from its anatomic location. Despite the widespread use of stereotactic radiosurgery (SRS) for cranial metastases, its specific impact on OCM remains underexplored. This study evaluates the efficacy and safety of CyberKnife SRS in treating OCM, focusing on occipital pain, dysfunctions of lower CNs, and local tumor control.

methodsWe retrospectively analyzed cases of OCM treated with SRS at our institute from 2012 to 2023, evaluating patient demographics, presenting symptoms, treatment parameters, and outcomes.

resultsEighteen patients (10 females) with a mean age of 64 years (SD: 10.4) were treated. Common presentations included occipital pain (44.4%) and lower CN deficits (27.8%). The median target volume was 6.95 cc (IQR: 4.64-21.2). The mean single-fraction equivalent dose was 18.7 Gy

conclusionCyberKnife SRS is a promising treatment of OCM, offering significant pain relief and improvement in neurological symptoms, along with favorable local control rates. This noninvasive therapy provides a valuable alternative to surgery, potentially enhancing the quality of life for patients with limited treatment options due to this challenging condition.

Indexed as

Bone metastasisCranial nervesHypoglossal nerveOccipital condyleSkull base metastasisStereotactic radiosurgery

Identifiers

PMID41163734
PMCPMC12560716

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.