Trial reportJournal of multidisciplinary healthcare2025
Effects of Oral Cholecalciferol on Chronic Wound Healing in Patients with Vitamin D Insufficiency or Deficiency.
Trial report in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Calcifediol Treatment Improves Skin Wound Healing in Vitamin D Deficiency Obese Rats.Pharmaceutics · 2026Article
- Baseline serum 25-hydroxyvitamin D levels as a predictor of periapical healing and clinical success after primary root canal treatment: A prospective, observational, and cohort study.Journal of conservative dentistry and endodontics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic wounds significantly impact patients' physical and mental health. Several individuals with chronic wounds have low vitamin D levels. Most previous studies have concentrated primarily on diabetic foot ulcers. Few investigations have explored the effects of vitamin D supplementation on different types of chronic wounds. Purpose: This study aimed to evaluate the impact of increasing serum 25-hydroxyvitamin D (25(OH)D) concentration on participants with chronic wounds and vitamin D insufficiency or deficiency following cholecalciferol (vitamin D3) supplementation. Additionally, it explored the combined effects of wound care and vitamin D supplementation on wound healing outcomes. Patients and Methods: A total of 46 participants with chronic wounds who were admitted to a wound ostomy care clinic between February and December 2023 were enrolled and randomly assigned to intervention (n=23) and control (n=23) groups. Both groups received local wound treatment based on the tissue, infection, moisture, and edge (TIME) principles and were advised on dietary changes and sunlight exposure. The intervention group received 6000 international units (IUs) of oral cholecalciferol daily until week 5, after which doses were adjusted based on serum concentration. Results: Of the 46 participants, 40 completed the study with 57 chronic wounds. Per-protocol analysis revealed a statistically significant difference in serum 25(OH)D concentration between the two groups at week 5 (mean ± standard deviation (SD): 36.75±7.23 vs 29.58±5.29 ng/mL, P<0.01). The intervention group had a shorter average wound healing time than the control group (mean ± SD: 15.59±6.27 vs 26.16±12.70 days, P<0.01). Additionally, wound area reduction rate, wound depth reduction rate, and pressure ulcer scale for healing (PUSH) scores were significantly higher in the intervention group (P<0.05). Conclusion: These findings suggest that oral cholecalciferol supplementation increases 25(OH)D concentrations and promotes chronic wound healing. Trial Registration: This trial was registered at the Chinese Clinical Trial Registry (https://www.chictr.org.cn/, Registration No. ChiCTR2200065482) on November 6, 2022.
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