Evidence map›Paper›PMID 41163679›Full record

ArticleFrontiers in endocrinology2025

Investigation on the relationship between renal NONO expression, fibrosis and prognosis in diabetic nephropathy.

Shuang Yang, Huiyuan Liao, Hanlu Ding, Xingli Xu

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Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Shuang YangDepartment of Nephrology, Sichuan Provincial People's Hospital, Sichuan Clinical Research Center for Kidney Diseases, Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Huiyuan LiaoDepartment of Nephrology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
Hanlu DingDepartment of Nephrology, Sichuan Provincial People's Hospital, Sichuan Clinical Research Center for Kidney Diseases, Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Xingli XuInstitute of Cardiovascular Diseases & Department of Cardiology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

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6 · The paper itself

Abstract

Background: Renal interstitial fibrosis (RIF) is an important manifestation of Diabetic nephropathy (DN) progression. Non-POU domain containing octamer-binding protein (NONO) is crucial in fibrosis in cardiovascular diseases, but its role in DN fibrosis remains unclear. This study explores the expression of NONO in DN and its correlation with Matrix Metalloproteinase-9 (MMP-9, as an important regulator of fibrosis), renal fibrosis, and prognosis. Methods: Forty patients with type 2 diabetes mellitus (T2DM) with pathologically confirmed DN were included, divided into early DN group (n=20) and late DN group (n=20). 6 normal renal tissue as control group. HE, Masson staining, immunohistochemical staining and Immunofluorescence double staining were performed. The correlation between NONO expression levels and MMP-9 as well as clinical pathological data was analyzed. Cox regression analysis and Kaplan-Meier survival curves were used to evaluate the relationship between renal tissue NONO expression levels and DN prognosis. Results: Compared with control group, NONO expression levels in renal tissues of DN patient were increased, and the late DN group was higher than the early DN group ( Conclusions: NONO expression levels correlate positively with MMP-9, collagen and renal damage indicators in renal tissues of DN patients. High NONO expression is linked to poor renal prognosis in DN. NONO may contribute to renal tissue fibrosis in DN by regulating MMP-9 levels.

Indexed as

Diabetes Mellitus, Type 2Diabetic NephropathiesKidneyRNA-Binding ProteinsAdultAgedFemaleFibrosisHumansMaleMatrix Metalloproteinase 9Middle AgedPrognosisMatrix Metalloproteinase 9MMP9 protein, humanRNA-Binding Proteinsdiabetic nephropathymatrix metalloproteinase-9non-POU domain containing octamer-binding proteinprognosisrenal interstitial fibrosis

Identifiers

PMID41163679
PMCPMC12558785

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