Evidence map›Paper›PMID 41163651›Full record

ArticleNeurosurgery practice2025

Clinical Characteristics and Mortality of Neurocritical Care Patients With Post-traumatic Cerebral Venous Outflow Compromise.

Tommi K Korhonen, Moritz Steinruecke, David Clark, Ivan Timofeev, Adel Helmy, Andrea Lavinio, Nicholas J Higgins, John Pickard, Peter Hutchinson, Angelos Kolias

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Article in Neurosurgery practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Tommi K KorhonenDivision of Neurosurgery, Department of Clinical Neurosciences, Cambridge University Hospitals NHS Foundation Trust & University of Cambridge, Cambridge, Cambridgeshire, UK.ORCID https://orcid.org/0000-0002-5500-9200
Moritz SteinrueckeDivision of Neurosurgery, Department of Clinical Neurosciences, Cambridge University Hospitals NHS Foundation Trust & University of Cambridge, Cambridge, Cambridgeshire, UK.
David ClarkDivision of Neurosurgery, Department of Clinical Neurosciences, Cambridge University Hospitals NHS Foundation Trust & University of Cambridge, Cambridge, Cambridgeshire, UK.
Ivan TimofeevDivision of Neurosurgery, Department of Clinical Neurosciences, Cambridge University Hospitals NHS Foundation Trust & University of Cambridge, Cambridge, Cambridgeshire, UK.
Adel HelmyDivision of Neurosurgery, Department of Clinical Neurosciences, Cambridge University Hospitals NHS Foundation Trust & University of Cambridge, Cambridge, Cambridgeshire, UK.
Andrea LavinioDepartment of Anaesthesia, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
Nicholas J HigginsDepartment of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
John PickardDivision of Neurosurgery, Department of Clinical Neurosciences, Cambridge University Hospitals NHS Foundation Trust & University of Cambridge, Cambridge, Cambridgeshire, UK.
Peter HutchinsonDivision of Neurosurgery, Department of Clinical Neurosciences, Cambridge University Hospitals NHS Foundation Trust & University of Cambridge, Cambridge, Cambridgeshire, UK.
Angelos KoliasDivision of Neurosurgery, Department of Clinical Neurosciences, Cambridge University Hospitals NHS Foundation Trust & University of Cambridge, Cambridge, Cambridgeshire, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe clinical characteristics and natural history of post-traumatic cerebral venous outflow compromise (VOC) are poorly characterized. We aimed to determine the prevalence of VOC in at-risk traumatic brain injury patients, assess its effect on long-term mortality, and describe our management practices.

methodsWe conducted a retrospective single-center case-control study. We included patients admitted to the neurocritical care unit after traumatic brain injury who had been investigated with computed tomography venography because of clinical suspicion of VOC between 2008 and 2015.

resultsA total of 89 patients underwent computed tomography venography during their neurocritical care unit admission. A total of 43 patients (48%, 32 male [74%], mean age 40 years [SD 16.2]) had evidence of VOC. Of these, 28 (65%) were due to an intraluminal dural venous sinus thrombosis (DVST) and 15 (35%) due to an extraluminal cause. Twelve (43%) of the DVSTs were occlusive, and 16 (57%) were nonocclusive. A total of 24 patients (27%) underwent decompressive craniectomy, which was more commonly performed for patients with an occlusive thrombosis than those with partial or no VOC (67% vs 23% vs 20%,

conclusionAmong those at risk, patients with evidence of post-traumatic VOC may have had higher short-term mortality, but VOCs did not increase long-term mortality rates compared with those without VOC. Patients with an occlusive thrombosis were more likely to undergo decompressive craniectomy. Most patients with a DVST received prophylactic rather than treatment-dose antithrombosis. Further studies are required to determine the optimal management of post-traumatic VOC.

Identifiers

PMID41163651
PMCPMC12560717

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