ArticleCureus2025
Neuroregenerative Treatment With Radio Electric Asymmetric Conveyer Technology in Advanced Childhood Cerebral X-linked Adrenoleukodystrophy: Clinical Stabilization and Electroencephalographic Evidence of Cortico-Subcortical Reorganization.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Reversal of Endogenous Bioelectrical Network Collapse in Advanced Childhood Cerebral X-Linked Adrenoleukodystrophy.Neurology international · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe the case of a male child with advanced childhood cerebral X-linked adrenoleukodystrophy (Loes score 15) who underwent five cycles of radio electric asymmetric conveyer (REAC) neuro regenerative (RGN-N) treatment over a two-year period. Clinical assessments and neurophysiological recordings were performed at baseline and during follow-up. The pre-treatment electroencephalogram (EEG) and brain mapping showed disorganized background activity for age, continuous bilateral frontal slowing, and abundant epileptiform discharges with right-sided predominance. Post-treatment evaluations performed four months after the last cycle revealed background activity appropriate for age, a reduction of slowing to intermittent focal changes confined to the left frontal region, and a restriction of epileptiform activity to a small area involving the right centro-rolandic region. Sustained clinical stabilization was observed, with decreased spasticity (Modified Ashworth Scale from 3 to 1), recovery of visual tracking, improved emotional responsiveness, and resolution of the conditions that had previously required repeated hospitalizations, along with discontinuation of oxygen therapy and airway suctioning. These findings contrast with the expected course of progressive deterioration in this condition and provide objective neurophysiological evidence of cortical reorganization associated with REAC RGN-N treatment. Further studies are warranted to explore the potential of this therapeutic approach in advanced stages of neurodegenerative disorders.
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Registered trials
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