Chemometric Optimization of BF

Arianna Bini, Lisa Rita Magnaghi, Valeria Cavalloro, Alessandra Bonanni, Stefano Protti, Daniele Merli

Abstract read

In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arianna BiniDepartment of Chemistry, University of Pavia, Viale Taramelli 10, Pavia, 27100, Italy.

Lisa Rita MagnaghiDepartment of Chemistry, University of Pavia, Viale Taramelli 10, Pavia, 27100, Italy.

Valeria CavalloroDepartment of Earth, Environmental Sciences, Via A. Ferrata 1, Pavia, 27100, Italy.

Alessandra BonanniDepartment of Chemistry, University of Pavia, Viale Taramelli 10, Pavia, 27100, Italy.

Stefano ProttiDepartment of Chemistry, University of Pavia, Viale Taramelli 10, Pavia, 27100, Italy.ORCID https://orcid.org/0000-0002-5313-5692

Daniele MerliDepartment of Chemistry, University of Pavia, Viale Taramelli 10, Pavia, 27100, Italy.

Funding

Ministero dell'Università e della Ricerca P2022TXJX8

6 · The paper itself

Abstract

The acid-catalyzed conversion of cannabidiol (CBD) to tetrahydrocannabinol and iso-tetrahydrocannabinol derivatives is a well-established synthetic strategy. However, since the reaction outcome is strongly dependent on the conditions, a careful investigation is always required to achieve the optimal chemoselectivity. Chemometrics recently emerged as an effective approach for improving synthetic methods, especially when multiple parameters are involved. The present paper aims to apply chemometrics tools to the optimization of the procedures for the preparation of Δ⁹-THC, Δ⁸-THC, Δ⁸-iso-THC, Δ⁴-iso-THC, and Δ⁴

Indexed as

cannabidiol (cbd)design of experiments (doe)lewis acid catalysisprincipal component analysis (pca)tetrahydrocannabinol derivatives (thcs)

Identifiers

PMID41163562

DOI10.1002/chem.202502387

PMCPMC12648456

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.