ArticleBrain and behavior2025
Spatial Orientation Impairment in Patients With Bilateral Vestibulopathy and Persistent Postural-Perceptual Dizziness.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Spatial Orientation Impairment in Patients With Bilateral Vestibulopathy and Persistent Postural-Perceptual Dizziness.Brain and behavior · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundTwo chronic forms of dizziness-bilateral vestibulopathy (BVP) with a loss of vestibular input, and functional dizziness with normal vestibular function-present with the key symptom of postural and gait imbalance. In BVP, this is associated with spatial disorientation. Here, we investigated whether persistent postural-perceptual dizziness (PPPD) in patients with normal vestibular function also affects spatial orientation, because there is evidence that central multisensory misintegration plays a crucial role in PPPD.
methodsThirty-two patients with BVP (mean age 52.44 ± 12.00 years; 17 females), 43 patients with PPPD (mean age 45.93 ± 11.72 years; 25 females), and 32 healthy controls (HC, mean age 44.78 ± 14.40 years; 15 females) participated in a clinical bedside test investigating spatial orientation abilities (three-dimensional real-world pointing task, 3D-RWPT). This test includes a cognitive (mental rotation) and a vestibular paradigm (body rotation around yaw axis with eyes closed). Participants reported their perceived spatial abilities and levels of spatial anxiety /orientation-related discomfort through standardized questionnaires.
resultsPatients with BVP and PPPD showed significantly lower accuracy (i.e., larger angular deviations) in the 3D-RWPT compared to HC (BVP: 9.62° ± 3.21°, PPPD: 9.16° ± 3.85°, HC: 7.77° ± 2.86°; p = 0.03), especially in the subtasks that rely on vestibular function (BVP: 8.11° ± 5.51°, PPPD: 6.62° ± 4.46°, HC: 4.45° ± 2.33°; p < 0.01). All cohorts had comparable levels of self-assessed spatial abilities, while both BVP and PPPD patients showed higher levels of spatial orientation discomfort.
conclusionsThis impairment of spatial orientation in PPPD patients with normal vestibular function could be a sign of (potentially anxiety-driven) central suppression of vestibular input, which is required for the continuous updating of the internal representation of body motion and position relative to the environment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.