Evidence map›Paper›PMID 41163333›Full record

ArticleBrain and behavior2025

Selective Hippocampal Subfield Atrophy Mediates Cognitive Decline in Cushing's Disease.

Zhebin Feng, Tao Zhou, Xinyuan Yan, Kunyu He, Hailong Liu, Xiaoteng Yu, Rong Lu, Zhiguo Ma, Xinguang Yu, Yanyang Zhang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhebin FengDepartment of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, China.
Tao ZhouDepartment of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, China.
Xinyuan YanDepartment of Psychiatry, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Kunyu HeDepartment of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, China.
Hailong LiuDepartment of Radiotherapy, Beijing Tiantan Hospital Capital Medical University, Beijing, China.
Xiaoteng YuDepartment of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China.
Rong LuDepartment of Neurosurgery, Chinese PLA 942 Hospital, Yinchuan, Ningxia, China.
Zhiguo MaDepartment of Neurosurgery, Chinese PLA 942 Hospital, Yinchuan, Ningxia, China.
Xinguang YuDepartment of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, China.
Yanyang ZhangDepartment of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing, China.ORCID https://orcid.org/0000-0003-2162-7358

Funding

National Natural Science Foundation of China 81871087National Natural Science Foundation of China 82001798National Science and Technology Major Project of the Ministry of Science and Technology of China 2022ZD0210100Young Talent Project of Chinese PLA General Hospital 20230403
6 · The paper itself

Abstract

backgroundCushing's disease (CD) provides insight into how prolonged high cortisol exposure affects brain structure. While CD patients show cognitive and emotional symptoms linked to hippocampal function and detailed analysis of hippocampal subfield changes remains limited.

methodsThe study included 91 patients with active CD and 53 matched healthy controls who underwent T1-weighted magnetic resonance imaging and comprehensive neuropsychological assessment. We employed voxel-based morphometry, automated segmentation, and shape analysis to evaluate gray matter volume, subfield volumes, and hippocampal morphology. Clinical correlations of hippocampal subfield volumes were also explored.

resultsCompared to controls, CD patients showed decreased hippocampal gray matter volume, particularly in the body and tail regions. Specific subfields, including presubiculum-body, subiculum-body, CA4-body, and granule cell layer, showed significant volume reductions. Shape analysis revealed corresponding surface alterations. Notably, left CA4-body and left GC-ML-DG-body volumes mediated the relationship between cortisol levels and cognitive performance.

conclusionsCD patients exhibit distinct patterns of hippocampal atrophy affecting specific subfields, with changes correlating to hormone levels and cognitive symptoms. These structural alterations may serve as potential biomarkers for CD and provide insight into the mechanisms underlying cognitive dysfunction in hypercortisolism.

Indexed as

Cognitive DysfunctionHippocampusPituitary ACTH HypersecretionAdultAtrophyFemaleGray MatterHumansHydrocortisoneMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsHydrocortisoneCognitiveCushing's diseasehippocampal subfieldshypercortisolism

Identifiers

PMID41163333
PMCPMC12571980

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.