ArticleInternational journal of dermatology2026
Comorbidities and Healthcare Utilization in 4197 Patients With Prurigo Nodularis in Israel: A Cross-Sectional Population-Based Analysis.
Article in International journal of dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Renal Disease Burden in Prurigo Nodularis: A Systematic Review and Meta-Analysis.International journal of dermatology · 2026Article
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Authors and funding
5 authors.
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Abstract
backgroundPrurigo nodularis patients face a significant burden of comorbidities, necessitating a comprehensive approach to care. We aimed to explore the association between prurigo nodularis, its comorbid conditions, and healthcare usage patterns.
methodsA population-based, cross-sectional study was conducted using the computerized medical data of Clalit Health Service, the largest health maintenance organization in Israel. We extracted data on all database members with prurigo nodularis between the years 2000 and 2022. Data was gathered from various sources, including primary care and hospital reports, as well as laboratory and imaging analyses. We compared 4197 prurigo nodularis patients with 40,771 matched controls (age, gender, socioeconomic status, ethnicity). Logistic regression was used to calculate odds ratios (OR) for comorbidities. Healthcare utilization and medication claims were also analyzed.
resultsThis study involved 4197 prurigo nodularis patients. Prurigo nodularis showed strong associations with various cutaneous and systemic comorbidities, mainly atopic dermatitis (odds ratio [OR] 5.74, 99.5% confidence interval [CI]: 4.85-6.80, p < 0.001), chronic renal failure and dialysis (OR 1.41, 99.5% CI: 1.15-1.72, p < 0.001), as well as a myriad of mental health disorders. Prurigo nodularis patients exhibited increased healthcare utilization and medication claims.
conclusionsThis study highlights the substantial comorbidity burden in prurigo nodularis patients, emphasizing the need for a holistic care approach. The study also underscores the importance of psychological screening and highlights the burden that prurigo nodularis and its associated disorders place on healthcare utilization. Future studies that include further research into prurigo nodularis pathogenesis and treatment strategies considering its systemic associations are warranted.
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