ArticleLipids in health and disease2025
Central obesity measured by waist-to-hip ratio independently predicts crohn's disease risk: a prospective cohort study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectiveThis study evaluated associations between several obesity indicators and the risks of Crohn's disease (CD) and ulcerative colitis (UC), the two principal clinical phenotypes of inflammatory bowel disease (IBD).
methodsData from 479,590 UK Biobank participants (mean age ± standard deviation: 56.5 ± 8.09 years; 54.5% female) were analyzed. Participants were classified based on waist circumference (WC). Cox proportional hazards models were used to quantify associations between multiple adiposity measures and incident CD and UC, adjusting for demographic, behavioral, and clinical covariates.
resultsDuring a median observation period of 12.5 years (maximum 15.6 years), 1,518 incident CD cases and 2,957 incident UC cases were identified. Taking into account demographic variables (age, sex, and ethnic background), lifestyle indicators (including smoking, alcohol intake, sleep, diet, physical exercise, and employment), socioeconomic status measured by the Townsend Deprivation Index(TDI), coexisting conditions (hypertension and diabetes), inflammatory status (C-reactive protein), and nonsteroidal anti-inflammatory drug consumption, waist-to-hip ratio (WHR)-defined central adiposity was found to elevate the risk of CD (hazard ratio [HR] 1.18; 95% confidence interval [CI] 1.05-1.34). However, WC-defined central obesity did not demonstrate a statistically significant link to CD risk (HR 1.11, 95% CI 0.97-1.27). In minimally adjusted models, WHR-defined central obesity was associated with an increased hazard of UC (HR 1.13; 95% CI 1.05-1.23); this association attenuated to non-significance after full covariate adjustment (HR 1.03; 95% CI 0.95-1.13). Obesity defined by BMI ≥ 30 showed no relation to CD, whereas it was associated with a lower hazard of UC (HR 0.86; 95% CI 0.78-0.95). Similarly, higher body-fat percentage (BFP: male > 25%, female > 35%) was associated with a modestly lower hazard of CD (HR 0.92; 95% CI 0.85-0.99). Excluding incident IBD events that occurred during the first 24 months of follow-up, the WHR-CD association persisted (HR 1.19; 95% CI 1.04-1.36). Additionally, individuals in the highest third of WHR-for-BMI residuals (> 66th percentile) exhibited a markedly elevated risk of CD (HR 1.26; 95% CI 1.10-1.44).
conclusionsCentral obesity, assessed by WHR, independently predicts the risk of CD, with a particularly pronounced effect in females, irrespective of BMI or other metabolic confounders. Conversely, higher BMI and BFP were inversely associated with UC risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.