ArticleBMC cancer2025
Burden, trends, driving factors, and predictions of gastric cancer: a cross-national comparative analysis of China, Japan, and South Korea.
Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Development of a postoperative risk scoring tool for elderly patients with early gastric cancer: an exploratory prognostic score derivation study.Journal of gastrointestinal oncology · 2026Article
- Tracking three decades of type 1 diabetes-related chronic kidney disease in East Asia: Burden, age-sex patterns, and quality of care index.Journal of diabetes investigation · 2026Article
- Rethinking gastric carcinogenesis: a multiscale ecological model of risk beyondFrontiers in microbiology · 2026Review
- Advances in epigenetics of gastric cancer.Oncology reviews · 2026Review
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5 authors.
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Abstract
backgroundGastric cancer (GC) is one of the most common malignancies globally. Despite advances in early screening and treatment, the burden of GC has decreased. But, its incidence and mortality rates remain high in East Asia, particularly in China, Japan, and South Korea.
methodsThis study based on the Global Burden of Disease (GBD) 2021 database, analyzes trends in GC burden from 1990 to 2021 and identifies key driving factors in China, Japan, South Korea, and globally. The Bayesian Age-Period-Cohort (BAPC) model was used for future predictions.
resultsFrom 1990 to 2021, the global GC burden showed a significant downward trend. The ge-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) decreased from 24.76/100,000 to 14.33/100,000 (EAPC=-1.81 [95% CI: -1.88,-1.75]) and 22.01/100,000 to 11.20/100,000 (EAPC=-2.26 [95% CI: (-2.34,-2.18]), respectively. China's ASIR decreased from 48.03/100,000 to 29.05/100,000 (EAPC=-1.64 [95% CI: -1.82,-1.47]). South Korea and Japan showed more significant reductions, with South Korea's ASIR dropping from 71.18/100,000 in 1990 to 25.76/100,000 in 2021 (EAPC=-3.54 [95% CI: -3.68,-3.41]), the fastest decline among all regions. Japan's ASIR decreased from 64.05/100,000 to 25.54/100,000 (EAPC=-2.98 [95% CI: -3.05,-2.92]). The decomposition analysis indicated that population aging was the major driver of the GC burden. Risk factors such as high-salt diet and smoking were strongly associated with GC.
conclusionThe findings emphasize the importance of early screening, health interventions, lifestyle changes and dietary adjustments in reducing GC burden, especially in high-risk countries.
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