Evidence map›Paper›PMID 41163101›Full record

ArticleArchives of public health = Archives belges de sante publique2025

Albumin-corrected anion gap and risk of mortality among US adults.

Ze-Bin Ni, Hong-Bin Zhang, Lian-Zhen Huang, Qi-Rong Yao, Shi-Cheng Wu, Wei-Feng Huang, Ji Li, Yan-Qing Wang, Jin-Yan Zhang

Abstract read
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In one paragraph

Article in Archives of public health = Archives belges de sante publique, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Ze-Bin Ni *Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, China.
Hong-Bin Zhang *Department of Physical Examination, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Lian-Zhen HuangDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, China.
Qi-Rong YaoDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, China.
Shi-Cheng WuThe School of Clinical Medicine, Fujian Medical University, Fuzhou, China.
Wei-Feng HuangDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, China.
Ji LiDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, China.
Yan-Qing WangDepartment of Ultrasound, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, China. xiaosirui2010@163.com.
Jin-Yan ZhangDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, No. 55 Zhenhai Road, Xiamen, 361003, China. dgh2023@xmu.edu.cn.

Funding

Medical and Health Guiding Project of Xiamen 3502Z20224ZD1009
6 · The paper itself

Abstract

backgroundElevated albumin-corrected anion gap (ACAG) has been linked to increased mortality across various patient populations, but its prognostic value in the general population remains unclear. This study examined the association between ACAG and all-cause, cardiovascular disease (CVD), and cancer mortality among US adults.

methodsData from 40,702 adults aged ≥ 20 years were analyzed from the National Health and Nutrition Examination Survey 1999-2018. ACAG was calculated as: anion gap + (4.4 - serum albumin [g/dL]) × 2.5. Cox proportional hazards models, restricted cubic splines, and Kaplan-Meier curves were used to assess associations. Subgroup and sensitivity analyses were conducted.

resultsOver a median 113 month follow-up, 6,087 deaths occurred, including 1,601 from CVD and 1,372 from cancer. Each 1-unit increase in ACAG was associated with higher risk of all-cause (HR = 1.08, 95% CI: 1.06-1.10), CVD (HR = 1.08, 95% CI: 1.05-1.12), and cancer mortality (HR = 1.06, 95% CI: 1.03-1.09). Participants in the highest ACAG quartile had significantly higher mortality risks compared to the lowest quartile. No evident nonlinear associations were observed for all-cause, CVD, and cancer mortality. The positive association with all-cause mortality was more pronounced among participants aged < 60 years, males, current smokers, and those with hyperlipidemia or diabetes. Sensitivity analyses confirmed robustness.

conclusionsElevated ACAG is independently associated with increased risks of all-cause, CVD, and cancer mortality in US adults. ACAG has potential value in stratifying mortality risk in public health contexts.

Indexed as

Albumin-corrected anion gapCancerCardiovascular diseaseMortalityNHANES

Identifiers

PMID41163101
PMCPMC12574005

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.