ArticleStem cell research & therapy2025
hPSC-derived sacral neural crest cells restore erectile function in pelvic ganglia injury.
Article in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- 3D-printed PCL scaffold coated with chitosan-hyaluronic acid hydrogel loaded with NGF-overexpressing UiPSC-derived neural crest cells restores erectile function via cavernous nerve regeneration.Bioactive materials · 2027Article
- Targeting the neuro-immune axis: immunological mechanisms and therapeutic strategies in male sexual dysfunction.Journal of neuroinflammation · 2026Review
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Authors and funding
10 authors.
Funding
Abstract
backgroundPelvic surgeries frequently injure the pelvic autonomic plexus, represented in rats by the major pelvic ganglia (MPG), resulting in refractory erectile dysfunction (ED) with limited therapeutic options. Sacral neural crest (NC) cells, the embryonic progenitors of MPG neurons and glial cells, offer a developmentally matched cell source for targeted neural repair.
methodsWe developed a stable and expandable sacral NC cell population derived from human pluripotent stem cells (hPSCs) and transplanted these cells into a rat model of MPG crush injury to assess engraftment efficacy and functional outcomes.
resultsTransplantation of sacral NC cells resulted in robust engraftment and significant erectile functional recovery, as evidenced by elevated intracavernosal pressure/mean arterial pressure (ICP/MAP) ratios. Mechanistically, MPG repair involves dual pathways: differentiation into nitrergic and cholinergic neurons and glial cells, which is coupled with the sustained secretion of neurotrophic factors (BDNF/GDNF/NGF). MPG restoration thereby re-established autonomic innervation of the penis, driving structural recovery characterized by reduced apoptosis and fibrosis, as well as the restoration of smooth muscle and endothelial integrity-essential for erectile functional rehabilitation.
conclusionsOur results demonstrate that hPSC-derived sacral NC cells represent a novel therapeutic strategy for neurogenic ED, restoring pelvic autonomic nerve structure and function through both neurogenic differentiation and sustained neurotrophic support.
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