SynthesisBMC women's health2025
Condylomata acuminata in the neovagina and vulva with HPV6/18 infection in a patient with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome after sheares' vaginoplasty: a case report and systematic review.
Synthesis in BMC women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMayer-Rokitansky-Küster-Hauser (MRKH) syndrome patients who undergo vaginoplasty are at risk of developing HPV-related lesions throughout their life, from low risk condylomata acuminata (CA) to cancerous lesions. However, the HPV status of neovaginal lesion in this patient group were often undocumented. We reported a case of CA, with HPV type 6 and 18 positive, affecting both the neovagina and vulva in a MRKH patient who underwent vaginoplasty (12 months ago). Additionally, we explore the relationship between HPV infection and neovaginal lesions through a review of current literatures. CASE PRESENTATION: A 21-year-old MRKH patient after vaginoplasty was diagnosed with condylomata acuminata in the neovagina and vulva and was HPV 6 and 18 positive. The colposcopy biopsy of the condylomata acuminata (CA) lesions in the neovagina confirmed a CA lesion, with positive immunohistochemistry (IHC) staining for low-risk HPV (lrHPV). The vulvar lesions were removed by cryoablation with liquid nitrogen, and the neovaginal lesions were treated with carbon dioxide laser ablation. Post-treatment follow up showed complete resolution of neovaginal and vulvar CA, with complete epithelization of the neovaginal lesions.
conclusionsMRKH patients who undergo vaginoplasty are at risk of developing HPV-related lesions throughout their life. This is the first published case of coinfection with both hrHPV and lrHPV, with lrHPV-related CA in an MRKH patient after Sheares' vaginoplasty. Routine HPV screening, HPV vaccination, and condom use should be indicated in this population.
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