Trial reportBMC oral health2025
Comparative evaluation of hyaluronic acid and injectable platelet-rich fibrin in palatal wound healing: a randomized clinical trial.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Efficacy of Injectable Platelet Rich Fibrin (I-TZF) Impregnated Gelatin Sponge and 0.8% Hyaluronic Acid Gel Impregnated Gelatin Sponge on Clinical Healing of Palatinal Wound Healing After Free Gingival Grafting.
Efficacy of Cross-linked Hyaluronic Acid in Improving Healing After Free Gingival Graft: a Randomized Controlled Clinical Trial
Who cites it
5 citing papers in PubMed.
- Effect of injectable platelet-rich fibrin on orthodontically induced apical root resorption following non-extraction-based orthodontic treatment in adults: A randomized controlled clinical trial.The Journal of international medical research · 2026Trial
- Comparison of injectable platelet-rich fibrin, titanium platelet-rich fibrin, and 0.8% hyaluronic acid applications versus periodontal dressing alone in wound healing after gingivectomy and gingivoplasty operations: randomized controlled clinical study.Clinical oral investigations · 2026Trial
- Review
- Hyaluronic Acid-Based Biomaterials for Soft Tissue Repair and Wound Healing: Clinical Evidence and Emerging Applications.Gels (Basel, Switzerland) · 2026Review
- The Emerging Role of Hyaluronic Acid as a Multifunctional Regenerative Agent in Periodontal Healing.Gels (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to compare the effects of locally applied hyaluronic acid (HA) and injectable platelet-rich fibrin (I-PRF) on patient morbidity, oral health-related quality of life (OHRQoL), and healing of palatal donor sites, palatal tissue consistency, complete epithelization (CE), and color match (CM). MATERIALS AND
methodsSixty-seven patients undergoing free gingival grafting (FGG) were randomly assigned to three groups in an examiner-masked clinical trial. Test group 1 received a 0.8% HA gel-impregnated gelatin sponge, test group 2 received an I-PRF-impregnated sponge, and the control group received a sterile sponge. Pain and burning were assessed via a visual analog scale (VAS) on days 3, 7, 14, and 21. CM was evaluated on days 3, 7, 14, 21, 28, and at months 1 and 3. CE and Landry Wound Healing Index (WHI) were recorded on days 3, 7, 14, 21, and 28.
resultsTopical application of hyaluronic acid (HA) and injectable platelet-rich fibrin (I-PRF) significantly reduced postoperative discomfort and improved complete epithelization (CE) compared to the control group (p < 0.05). HA showed better outcomes than I-PRF in wound healing and morbidity, while I-PRF also significantly reduced postoperative pain (p < 0.05). Palatal tissue thickness at the 1st and 3rd months differed significantly among groups (p = 0.001), and OHRQoL scores decreased significantly from day 7 to day 14 in all groups (p < 0.05).
conclusionThe adjunctive use of HA or I-PRF with gelatin sponge is more effective in minimizing discomfort and enhancing healing at palatal donor sites than sponge use alone. CLINICAL RELEVANCE: Optimizing healing and minimizing patient discomfort at palatal donor sites are crucial for improving outcomes in free gingival grafting procedures. This study demonstrates that the adjunctive application of HA or I-PRF significantly enhances soft tissue healing and reduces postoperative morbidity. Particularly, HA was found to be more effective in promoting wound healing and comfort. These findings support the clinical use of HA or I-PRF as simple, biocompatible adjuncts to improve patient experience and surgical outcomes in periodontal procedures. CLINICAL TRIAL NUMBER: NCT06867055 https://www. CLINICALTRIALS: gov 03/04/2025'Retrospectively registered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.