Evidence map›Paper›PMID 41162965›Full record

ArticleWorld journal of surgical oncology2025

Prognostic significance of lymph node yield in pelvic lymph node dissection for bladder cancer: population-based study.

Wei He, Ziwei Wang, Maoyu Wang, Qing Chen, Chen Zhang, Yue Wang, Xufeng Yu, Yi Wang, Hui Zhang, Jiaxin Xie and 4 more

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In one paragraph

Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Wei He *Department of Urology, The First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Ziwei Wang *Department of Urology, The First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Maoyu Wang *Department of Urology, The First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Qing ChenDepartment of Urology, The First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Chen ZhangDepartment of Urology, The First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Yue WangDepartment of Urology, The First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Xufeng YuDepartment of Urology, The First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Yi WangDepartment of Urology, The First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Hui ZhangDepartment of Urology, The First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Jiaxin XieDepartment of Urology, The First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Xuncheng YangDepartment of Urology, The First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Zhensheng ZhangDepartment of Urology, The First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China.
Chuanliang Xu *Department of Urology, Shanghai First People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, China. Chuanliang_xu@126.com.
Shuxiong Zeng *Department of Urology, The First Affiliated Hospital, Naval Medical University, Shanghai, 200433, China. zengshuxiong@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRadical cystectomy (RC) with neoadjuvant chemotherapy (NAC) and pelvic lymph node dissection (PLND) is standard for muscle-invasive bladder cancer (MIBC). While PLND improves staging and local control, the optimal extent is debated. This study used the SEER database (2000–2021) to evaluate lymph node yield's (LNY) prognostic significance.

methodsWe included 12,698 patients who underwent PLND, stratified by LNY quartiles (cutoffs at 12, 19, and 29). Inverse probability of treatment weighting (IPTW) was applied to balance baseline characteristics. Cox regression, Kaplan–Meier curves, and competing risk models assessed the impact of LNY on overall survival (OS) and cancer-specific survival (CSS). A prognostic nomogram incorporating LNY was developed and validated using LASSO regression, the area under the curve (AUC) and calibration plots.

resultsThe optimal threshold for LNY was determined to be 12, with LNY ≥ 12 associated with a 17% reduction in all-cause mortality risk (HR 0.83, 95% CI 0.79–0.88). An increase in LNY was correlated with improvements in OS and CSS, with the 5-year OS rate increasing from 46.0% to 55.6%. A nonlinear relationship between LNY and all-cause mortality risk was observed, as the protective effect diminished after exceeding 39.

conclusionsThis study supports the establishment of LNY threshold of 12 as an indicator of surgical completeness; an LNY of 20–39 may be associated with a sustained protective effect. However, excessive LNY may not yield additional benefits. Clinical decision-making should consider patient characteristics and healthcare accessibility to optimize outcomes for bladder cancer.

Indexed as

CystectomyLymph Node ExcisionLymph NodesUrinary Bladder NeoplasmsAgedFemaleHumansLymphatic MetastasisMaleMiddle AgedNomogramsPelvisPrognosisSEER ProgramSurvival RateBladder cancerLymph node yieldPelvic lymph node dissectionPrognosisSEER

Identifiers

PMID41162965
PMCPMC12574139

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.