ArticleBMC infectious diseases2025
Correlation between antimicrobial resistance and virulence in carbapenem-resistant Klebsiella pneumoniae at colonization and infection stages.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Evolving Clonal, Plasmid-Mediated Resistome, Virulome and Therapeutic Landscape of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026Article
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Authors and funding
8 authors.
Funding
Abstract
objectiveCarbapenem-resistant Klebsiella pneumoniae (CRKP) has emerged as a critical global public health. To investigate the dynamic changes of drug resistance genes and virulence traits in carbapenem-resistant Klebsiella pneumoniae during colonization-infection transitions, supporting clinical prevention strategies.
methodsA total of 18 cases each of CRKP colonization-to-infection and infection-to-colonization were enrolled from ICU patients. Genomic DNA from 72 isolates was used for PCR detection of resistance genes, virulence genes, and capsular serotype genes among the 72 isolates. KPC-positive isolates underwent Sanger sequencing for subtyping, and the string test was employed to assist in defining the hypervirulent phenotype.
resultsNo significant differences were observed in clinical features between groups. All isolates carried bla
conclusionCRKP maintains stable resistance genes during colonization-infection transitions, but dynamic virulence changes indicate higher infection risks when colonization converts to infection. Enhanced monitoring of virulence and resistance is critical to control hv-CRKP spread in ICUs.
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