Evidence map›Paper›PMID 41162901›Full record

ArticleThe journal of headache and pain2025

Swimming exercise alleviates peripheral neuropathic pain by downregulating FTO and promoting m

Ya-Nan Zheng, Yi-Li Zheng, Hui Liu, Si-Qiang Ren, Sheng-Jie Guo, Ting Sun, Jing-Yi Guan, Yu-Qin Shi, Pei-Jie Chen, Xue-Qiang Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ya-Nan Zheng *Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, 200438, China.
Yi-Li Zheng *Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, 200438, China.
Hui LiuDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, 200438, China.
Si-Qiang RenDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, 200438, China.
Sheng-Jie GuoDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, 200438, China.
Ting SunDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, 200438, China.
Jing-Yi GuanDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, 200438, China.
Yu-Qin ShiDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, 200438, China.
Pei-Jie ChenDepartment of Sport Rehabilitation, Shanghai University of Sport, Shanghai, 200438, China. chenpeijie@sus.edu.cn.
Xue-Qiang WangRehabilitation Medicine Center, The Second Affiliated Hospital of Wenzhou Medical University, 109 Xueyuan W Rd, Lucheng District, Wenzhou, Zhejiang, 325027, China. wangxueqiang@wmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Swimming exercise may alleviate neuropathic pain (NP) in spared nerve injury (SNI) mice by regulating pain-related genes, such as miR-183 and Cacna2d2. However, the related upstream mechanism remains unclear. The demethylase fat-mass and obesity-associated protein (FTO) in the dorsal root ganglia (DRG) participates in NP through m

Indexed as

Alpha-Ketoglutarate-Dependent Dioxygenase FTOMicroRNAsNeuralgiaPhysical Conditioning, AnimalSwimmingAnimalsDisease Models, AnimalDown-RegulationFemaleGanglia, SpinalMaleMethylationMiceMice, Inbred C57BLMice, KnockoutAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, mouseMicroRNAsMirn183 microRNA, mouseBrain-derived neurotrophic factorCaV α2δ-2Dorsal root gangliaExerciseFat-mass and obesity-associated proteinsM6A methylationMiR-183Neuropathic pain

Identifiers

PMID41162901
PMCPMC12570711

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.