Evidence map›Paper›PMID 41162871›Full record

SynthesisBMC cardiovascular disorders2025

Association between multiple pregnancy with peripartum cardiomyopathy: a systematic review and meta-analysis.

Triwedya Indra Dewi, Azizah Muthiah, Chaerul Achmad, Firman Fuad Wirakusumah, Ruswana Anwar, Annisa Dewi Nugrahani, Delvac Oceandi

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Triwedya Indra DewiDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia. triwedya.indra.dewi@unpad.ac.id.
Azizah MuthiahDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.
Chaerul AchmadDepartment of Cardiology and Vascular Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.
Firman Fuad WirakusumahDepartment of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.
Ruswana AnwarDepartment of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.
Annisa Dewi NugrahaniDepartment of Obstetrics and Gynecology, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.
Delvac OceandiDivision of Cardiovascular Science, The University of Manchester, Manchester, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWhile the diagnostic criteria for peripartum cardiomyopathy (PPCM) have been better established than other forms of cardiomyopathies in pregnancy, its pathogenesis and association with multiple pregnancies are still poorly understood, and there has never been an established meta-analysis regarding this study. Therefore, this study aims to evaluate the association between multiple pregnancies and the development of PPCM.

methodsWe conducted a comprehensive literature search using several databases, including PubMed, Scopus, and ScienceDirect, until May 31th, 2025. Studies were eligible if they investigated the association between multiple pregnancies and the probability of PPCM. Data were analyzed using a random effects model of pooled odds ratios (ORs) with the Mantel-Haenszel method.

resultsThis meta-analysis included one prospective and ten retrospective observational studies, with a total of 11,523,332 participants from eight different countries. Our study revealed that multiple pregnancies were significantly associated with an increased risk of developing PPCM (OR = 2.59 (95% CI = 2.17-3.10); P = < 0.00001; I

conclusionMultiple pregnancies demonstrated a significant association with the risk of PPCM development; hence, screening in this high-risk group is required.

Indexed as

CardiomyopathiesPregnancy Complications, CardiovascularPregnancy, MultipleAdultFemaleHumansObservational Studies as TopicPeripartum CardiomyopathyPeripartum PeriodPregnancyPrognosisRisk AssessmentRisk FactorsMultiple gestationMultiple pregnancyPeripartum cardiomyopathy

Identifiers

PMID41162871
PMCPMC12570570

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.