ArticleEuropean journal of clinical investigation2026
ANGPTL8 is upregulated in subcutaneous adipose tissue at early term after bariatric surgery in patients living with obesity.
Article in European journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Safety and Effectiveness of Metabolic and Bariatric Surgery Before and After Kidney Transplantation: A Systematic Review and Meta-Analysis.Obesity surgery · 2026Pooled it
- ANGPTL8 is upregulated in subcutaneous adipose tissue at early term after bariatric surgery in patients living with obesity.European journal of clinical investigation · 2026Article
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Authors and funding
15 authors.
Funding
Abstract
objectiveOur aim is to study proteomic and transcriptomic changes in the subcutaneous white adipose tissue (sWAT) from patients living with severe obesity at early term after bariatric surgery (BS).
methodsTwenty-two sWAT biopsies were collected at the time of surgery and 3 months afterward (11 for each point and from the same patient). Clinical data and metabolic parameters were measured. Targeted proteomic profiling and RNA sequencing were conducted. Bioinformatic analyses were performed to identify differentially expressed proteins and genes and their associated pathways.
resultsEarly-term after BS leads to significant reductions in some clinical parameters. Twenty inflammatory proteins, including cytokines, chemokines and immune-regulatory factors were increased after BS. Transcriptomic profiling revealed 277 significantly modulated genes (156 upregulated, 121 downregulated). ANGPTL8 was notably increased after BS and enrichment analyses highlighted its association with extracellular matrix remodelling, insulin signalling pathway, calcium metabolism and energy and lipid metabolism.
conclusionsBS induces early immunological and transcriptomic modulations in sWAT, suggesting a transient pro-inflammatory state and tissue remodelling process. The ANGPTL8 upregulation could play a role in improving metabolic homeostasis at early term after BS. These findings offer new insights into adipose tissue remodelling after BS.
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