ArticleJournal of hepato-biliary-pancreatic sciences2025
Early Definitive Surgery for Congenital Biliary Dilatation in Children Is Associated With Lower Morbidity: Comparison of Infant and School-Age Children From 231 Consecutive Cases in a Multicenter Study in the Kyushu Area of Japan During the Past Decade.
Article in Journal of hepato-biliary-pancreatic sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThere has been little discussion on the differences in characteristics and long-term outcomes of congenital biliary dilation (CBD) by age group.
methodsWe conducted a regional multicenter study to investigate all pediatric cases of CBD in the Kyushu area of Japan over the past decade. Patient background, operative results, and postoperative complications were investigated. Results were compared between preschool children under 7 years of age and school-age children over 7 years of age.
resultsA total of 187 preschool children and 44 school-aged children with CBD were included. The preschool group had a significantly shorter operative time and lower blood loss. The school-age group had significantly more biliary leakage (4.8% vs. 13.6%, p = 0.03) and more anastomotic stenosis (2.1% vs. 9.1%, p = 0.02). For biliary leakage and anastomotic stenosis, an ROC analysis demonstrated the moderate predictive power for age in months at surgery (AUC = 0.739, 95% CI: 0.577-0.901), with 75.0% sensitivity and 74.0% specificity at a cutoff value of 65.0.
conclusionsRelative to preschool children, school-age children were more likely to suffer postoperative complications such as biliary leakage and anastomotic stenosis. Early definitive surgery in the infantile period is recommended for pediatric CBD.
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