ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2025
Disruption of quorum sensing and biofilm formation in Pseudomonas aeruginosa by plant-based O-methylated flavonoids.
Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Plant-Derived Compounds as Antibiotic Adjuvants Against Drug-Resistant ESKAPE Pathogens: Mechanisms of Action, Synergistic Strategies, and Translational Challenges.Antibiotics (Basel, Switzerland) · 2026Review
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Authors and funding
5 authors.
Funding
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Abstract
Anti-virulence strategies are gaining recognition as promising alternatives for bacterial infection control. They act by suppressing quorum sensing circuits, disrupting biofilm formation, and inhibiting toxin production. However, the emergence of resistant bacterial mutants highlights the need for anti-virulence agents that do not induce resistance. Pseudomonas aeruginosa produces autoinducers like N-acyl-homoserine lactone (AHL), which enhance cell-population and coordinate gene expression. Plant-derived compounds, particularly O-methylated phenolic flavonoids, have shown promise in overcoming antibiotic resistance. Herein, compounds such as formononetin (isoflavone) and 4'-methoxyflavonol (flavonol) possess pharmacological properties beneficial for human health and have been found to inhibit AHL-mediated virulence factors in P. aeruginosa. These flavonoids effectively reduced the production of virulence factors like exopolysaccharides, elastase, protease, pyocyanin, and rhamnolipids assessed by biochemical assays. Motility assays demonstrated a reduction in bacterial movement, and biofilm formation was quantified and visualized using Zeiss Confocal Laser Scanning Microscopy. Gene expression analysis by RT-qPCR revealed that the flavonoids suppressed las and rhl circuits associated with virulence factor synthesis. Among the selected two compounds, 4'-methoxyflavonol exhibited the strongest inhibitory effect against P. aeruginosa. Overall, this study underscores the dual role of dietary phenolic flavonoids in supporting biological functions and serving as natural anti-quorum sensing agents, offering promising strategies to mitigate bacterial virulence.
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Registered trials
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