Evidence map›Paper›PMID 41162777›Full record

ArticleClinical oral investigations2025

Screening for objective indicators in pulp blood to distinguish the degree of pulpitis.

Jiaqi Chen, Siyi Liu, Weiyu Gong, Lin Zhu, Jingyi Li, Jilin Wu, Yanmei Dong

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Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jiaqi Chen *Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, P.R. China.
Siyi Liu *Department of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, P.R. China.
Weiyu GongDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, P.R. China.
Lin ZhuDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, P.R. China.
Jingyi LiDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, P.R. China.
Jilin WuDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, P.R. China.
Yanmei DongDepartment of Cariology and Endodontology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, P.R. China. kqdongyanmei@bjmu.edu.cn.ORCID 0000-0002-2749-7788

Funding

Beijing Municipal Science & Technology Commission Z211100002921042Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University 2023SZ-ZX02Michigan Medicine-Peking University Health Science Center Joint Institute BMU2022JI007Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases PKUSSNMP-202018
6 · The paper itself

Abstract

objectivesThis study aimed to (1) evaluate the accuracy of pulp blood color parameters-L* (brightness) and a* (red chroma)-in assessing the clinical severity of pulp inflammation; (2) identify key biomarkers in pulp blood associated with pulp inflammation degree. MATERIALS AND

methodsTeeth in clinical cases were categorized into four groups based on pre-operative diagnosis and intra-operative microscopic evaluation of the dentine, exposed pulp tissue, and bleeding. Group 1 included intact teeth with normal pulp as the control group. Groups 2, 3 and 4 were teeth with carious pulp exposure: Group 2 exhibited no signs of infection in the pulp tissue or surrounding dentine; Group 3 exhibited infected pulp tissue or dentin surrounding the exposure that was confined to the coronal portion; and Group 4 had infected pulp tissue extending into the radicular pulp. Pulp blood samples were obtained from pulp exposure sites of above teeth. After centrifugation, twenty inflammatory biomarkers in the supernatant of pulp blood were quantified using a multiplex immunoassay. Color parameters (L* and a*) of the residual pulp blood samples were measured using a spectrophotometer. One-way ANOVA was used to compare the L* and a* values across groups. The Kruskal-Wallis test was used to compare biomarker levels. The level of significance was set at 2-tailed P < 0.05.

resultsA total of 97 cases were included in the final analysis: Group 1 (n = 25), Group 2 (n = 17), Group 3 (n = 25) and Group 4 (n = 30). With increasing clinical inflammation severity from Groups 1 to 4, the L* value of pulp blood significantly decreased, while the a* value increased (P < 0.05). Compared to Group 1, the levels of MMP-9, IL-1β, osteoactivin, OPN, IL-8 and the IL-8/IL-10 and IL-6/IL-10 ratios in pulp blood were significantly higher in Group 2, 3 and 4 (P < 0.05), while the levels of TGF-β1 presented with the opposite trend (P < 0.01).

conclusionsColor characteristics and molecular biomarkers in pulp blood could serve as objective indicators for assessing pulp inflammation degree and may further provide a basis for selecting vital pulp therapy strategies. CLINICAL RELEVANCE: These findings have the potential to enhance the diagnostic accuracy of pulpitis and support clinical decision-making in vital pulp therapy, ultimately improving clinical outcomes and tooth survival.

Indexed as

Dental PulpPulpitisAdolescentAdultBiomarkersColorFemaleHumansMaleSeverity of Illness IndexSpectrophotometryBiomarkersColorMolecular biomarkerPulp bloodPulpitis diagnosisVital pulp therapy

Identifiers

PMID41162777

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