ArticleThe EMBO journal2025
Distinct senotypes in p16- and p21-positive cells across human and mouse aging tissues.
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Article in The EMBO journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
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Who cites it
34 citing papers in PubMed.
- Methylation-associated Gene Expression (MaGE): a non-invasive, in vivo measure of cellular senescence.medRxiv : the preprint server for health sciences · 2026Article
- RamanOmics decodes the spatial vibrational-molecular architecture of senescence in aging and repair.Nature aging · 2026Article
- Cellular senescence and the SASP in skeletal ageing: convergent mechanisms of progressive bone loss in osteoporosis.Biogerontology · 2026Review
- Review
- Timing-Dependent Clearance of p16-Positive Cells Mitigates Radiation-Induced Accelerated Aging.Aging cell · 2026Article
- Angiogenesis in Lung Regeneration and Aging.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- The immunology behind inflammaging-causes, sources, and mechanisms.The Journal of allergy and clinical immunology · 2026Review
- Isomucronulatol attenuates liver aging by inhibiting GSK-3β acetylation and promoting β-catenin accumulation.Journal of natural medicines · 2026Article
- Inhibiting cyclin D1-CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline.Nature aging · 2026Article
- 3D-Printable and Bioelectronic-Compatible Graphene-Reinforced PLA Nanocomposites Rejuvenate Aged Bone Regeneration Through Glycolytic Reprogramming.Advanced healthcare materials · 2026Article
- Senotypes define the diverse landscape of senescent cells.Nature aging · 2026Review
- Microbiome-derived metabolites shape CD4+ T cell differentiation and immune aging in HIV-1 infection.JCI insight · 2026Article
- Bazi Bushen Capsule restores fertility by targeting mitochondrial health in aging endometrium.iMeta · 2026Article
- Biomarkers of Inflammaging and Cellular Senescence in Musculoskeletal (MSK) Diseases: The Knowns and the Unknowns.Biomedicines · 2026Article
- A cross-talk between p16High senescence and cellular reprogramming.Clinical science (London, England : 1979) · 2026Review
- Transcription-independent induction of rapid-onset senescence is integral to healing.Nature cell biology · 2026Article
- Cellular senescence as a therapeutic target for aging intervention.Biomedical journal · 2026Review
- Regulation of T Cell Senescence in Health and Diseases.Immune network · 2026Review
- Senescent cells in systemic aging: SASP heterogeneity, immune escape, and endocrine modulation.Biogerontology · 2026Review
- Towards a context-aware framework for cellular senescence.Biogerontology · 2026Review
Corrections and comments
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Authors and funding
17 authors.
Dominik SaulDivision of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. dominik.saul@med.uni-goettingen.de.ORCID http://orcid.org/0000-0002-0673-3710
Diana JurkRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.
Madison L DoolittleDivision of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.
Robyn Laura KosinskyRobert Bosch Center for Tumor Diseases, Stuttgart, Germany.
Yeaeun HanRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.ORCID http://orcid.org/0000-0003-1122-3691
Xu ZhangRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.
Ana Catarina FrancoRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.
Sung Y KimDepartment of Biochemistry, Konkuk University School of Medicine, Seoul, Republic of Korea.
Saranya P WylesDepartment of Dermatology, Mayo Clinic, Rochester, MN, 55905, USA.
Y S PrakashDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA.
David G MonroeDivision of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA.
Luigi FerrucciIntramural Research Program, National Institute on Aging, NIH, Baltimore, MD, USA.
Nathan K LeBrasseurRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA.ORCID http://orcid.org/0000-0002-2002-0418
Paul D RobbinsInstitute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Laura J NiedernhoferInstitute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN, USA.
Sundeep KhoslaDivision of Endocrinology, Mayo Clinic, Rochester, MN, 55905, USA. Khosla.Sundeep@mayo.edu.ORCID http://orcid.org/0000-0002-2936-4372
João F PassosRobert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, 55905, USA. passos.joao@mayo.edu.ORCID http://orcid.org/0000-0001-8765-1890
Funding
Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, Nathan K LeBrasseur · 2019 to 2026
$28.7MValidation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JAN VIJG · 2017 to 2026
$24.5MMidwest Murine-Tissue Mapping Center (MM-TMC)U54AG079754 · NIA · UNIVERSITY OF MINNESOTA · PI GR Scott Budinger, Sundeep Khosla · 2022 to 2026
$11.5MMinnesota Tissue Mapping Center for Senescent CellsU54AG076041 · NIA · UNIVERSITY OF MINNESOTA · PI LAURA Jane NIEDERNHOFER · 2021 to 2026
$10.5MUsing the senolytic fisetin to suppress mortality in aged mice acutely exposed to murine beta-coronavirusR01AG063543 · NIA · UNIVERSITY OF MINNESOTA · PI NIEDERNHOFER, LAURA JANE · 2019 to 2023
$3.4MSenescence and Growth Differentiation Factors as Modifiers of AgingR01AG055529 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K · 2018 to 2022
$3.1MDefining the interactions of senescent immune cells and skeletal cellsR01AG076515 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, David G Monroe · 2022 to 2026
$2.4MThe role of sub-lethal mitochondrial apoptotic stress in cellular senescenceR01AG068048 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2020 to 2024
$2.2MDoes obesity exacerbate age-related cognitive decline via senescence?R01AG068182 · NIA · MAYO CLINIC ROCHESTER · PI JURK, DIANA · 2020 to 2024
$2.0MDevelopment of machine learning software to quantitatively map telomere induced senescence in tissue sections during agingUH3CA268103 · NCI · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2023 to 2025
$1.6MCharacterization of senescent cell populations in skeletal agingR01AG086085 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, David G Monroe · 2024 to 2026
$1.6MInvestigating the role of cytosolic mitochondrial double-stranded RNA in cellular senescence and agingR01AG082708 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2023 to 2025
$1.5MHevolution HR-GRO-23-1199144-8HHS | National Institutes of Health (NIH) R01AG068048; R01AG827; UG3CA26810308; UH3CA268103HHS | National Institutes of Health (NIH) R01AG07651HHS | National Institutes of Health (NIH) R01AG82708National Research Foundation of Korea (NRF) 2020M3A9D8038014NCI NIH HHS UG3 CA268103NCI NIH HHS UH3 CA268103NIA NIH HHS P01 AG062413NIA NIH HHS R01 AG055529NIA NIH HHS R01 AG063543NIA NIH HHS R01 AG068048NIA NIH HHS R01 AG068182NIA NIH HHS R01 AG076515NIA NIH HHS R01 AG082708NIA NIH HHS R01 AG086085NIA NIH HHS U19 AG056278NIA NIH HHS U54 AG076041NIA NIH HHS U54 AG079754
Abstract
Senescent cells drive age-related tissue dysfunction via the induction of a chronic senescence-associated secretory phenotype (SASP). The cyclin-dependent kinase inhibitors p21
Indexed as
AgingCellular SenescenceCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21Senescence-Associated Secretory PhenotypeAnimalsHumansMiceSingle-Cell AnalysisCDKN1A protein, humanCdkn1a protein, mouseCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21AgingCellular SenescenceHeterogeneitySenescence-Associated Secretory Phenotype (SASP)Single-Cell Mapping
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.