Altered Expression of Calpastatin by Hypoxia Regulates Trophoblast Cell Function through Mitochondria Associated Endoplasmic Reticulum Membranes.

Cui Zhang, Jingjing Jiang, Hongfang Kong, Xuyuan Ma, Haiyan Li, Hong Xin

Abstract read

In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cui ZhangDepartment of Obstetrics, Hebei General Hospital, Hebei Medical University, Shijiazhuang, China.

Jingjing JiangDepartment of Obstetrics, Hebei General Hospital, Hebei Medical University, Shijiazhuang, China.

Hongfang KongDepartment of Obstetrics, The Second Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China.

Xuyuan MaDepartment of Obstetrics, The Second Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China.

Haiyan LiDepartment of Obstetrics and Gynecology Ultrasound, The Second Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China.

Hong XinDepartment of Obstetrics, The Second Hospital of Hebei Medical University, Hebei Medical University, Shijiazhuang, China. 26200614@hebmu.edu.cn.ORCID 0009-0009-2581-5795

Funding

Hebei Province Science and Technology Support Program 21377707D

6 · The paper itself

Abstract

Preeclampsia (PE), a severe pregnancy complication, arises from placental hypoxia-induced mitochondrial and endoplasmic reticulum (ER) oxidative stress, contributing to inadequate spiral artery remodeling and endothelial dysfunction. Calpastatin, a mitochondrial protective protein, mitigates oxidative stress-related pathologies, but its role in PE remains unclear. This study investigated the effects of Calpastatin on trophoblast cellular proliferation, migration, invasion, apoptosis, and the expression of autophagy protein (PINK1), mitochondrial dynamics protein (Mfn2), ER stress protein (GRP78), ATP, Ca

Indexed as

Calcium-Binding ProteinsEndoplasmic ReticulumMitochondriaTrophoblastsApoptosisCell HypoxiaCell LineCell MovementCell ProliferationEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressFemaleGTP PhosphohydrolasesHumansMembrane Potential, MitochondrialMitochondria Associated MembranesCalcium-Binding ProteinscalpastatinEndoplasmic Reticulum Chaperone BiPGTP PhosphohydrolasesHSPA5 protein, humanMFN2 protein, humanMitochondrial ProteinsEndoplasmic reticulumMitochondriaOxidative stressPreeclampsiaTrophoblasts

Identifiers

PMID41162732

DOI10.1007/s43032-025-01995-4

PMCPMC12696053

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.