Evidence map›Paper›PMID 41162712›Full record

ArticleNature2025

Helicase-mediated mechanism of SSU processome maturation and disassembly.

Olga Buzovetsky, Sebastian Klinge

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Exchange dynamics and kinetic control of gene regulation complexes.Nature reviews. Molecular cell biology · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. A Chromatin Biology Assessment of AlphaFold3.bioRxiv : the preprint server for biology · 2026
    Article
  6. RiboScreenBiomedicines · 2026
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Olga BuzovetskyLaboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, New York, USA.
Sebastian KlingeLaboratory of Protein and Nucleic Acid Chemistry, The Rockefeller University, New York, New York, USA. klinge@rockefeller.edu.ORCID 0000-0002-9373-4737

Funding

Mechanisms of ribosome assemblyR35GM156426 · NIGMS · ROCKEFELLER UNIVERSITY · PI Sebastian Klinge · 2025 to 2026
$1.4M
Assembly of the eukaryotic small ribosomal subunitR01GM145950 · NIGMS · ROCKEFELLER UNIVERSITY · PI KLINGE, SEBASTIAN · 2022 to 2024
$1.0M
NIGMS NIH HHS R01 GM145950NIGMS NIH HHS R35 GM156426
6 · The paper itself

Abstract

Eukaryotic ribosomal small subunit (SSU) assembly requires the SSU processome, a nucleolar precursor containing the RNA chaperone U3 small nucleolar RNA (snoRNA). The underlying molecular mechanisms of SSU processome maturation, remodelling, disassembly and RNA quality control, and the transitions between states remain unknown owing to a paucity of intermediates

Indexed as

DEAD-box RNA HelicasesRibosome Subunits, Small, EukaryoticRNA HelicasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsExosome Multienzyme Ribonuclease ComplexExosomesModels, MolecularRNA PrecursorsRNA, Small NucleolarRNA StabilityDEAD-box RNA HelicasesExosome Multienzyme Ribonuclease ComplexMTR4 protein, S cerevisiaeRNA HelicasesRNA PrecursorsRNA, Small NucleolarRNA, U3 small nucleolarSaccharomyces cerevisiae Proteins

Identifiers

PMID41162712
PMCPMC12711562

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.