Evidence map›Paper›PMID 41162707›Full record

ArticleNature2025

Mechanism of conductance control and neurosteroid binding in NMDA receptors.

Hyunook Kang, Ruben Steigerwald, Elijah Z Ullman, Max Epstein, Srinu Paladugu, Dennis C Liotta, Stephen F Traynelis, Hiro Furukawa

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hyunook KangW.M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0002-7017-4597
Ruben SteigerwaldW.M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Elijah Z UllmanDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-6122-023X
Max EpsteinW.M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Srinu PaladuguDepartment of Chemistry, Emory University, Atlanta, GA, USA.
Dennis C LiottaDepartment of Chemistry, Emory University, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-7736-7113
Stephen F TraynelisDepartment of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-3750-9615
Hiro FurukawaW.M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. furukawa@cshl.edu.ORCID http://orcid.org/0000-0001-8296-8426

Funding

Structures and reagents of NMDA receptorsR01MH085926 · NIMH · COLD SPRING HARBOR LABORATORY · PI Hiroyasu Furukawa · 2010 to 2026
$8.9M
Structure and Function of Hetero-Multimeric Ligand-Gated Ion ChannelsR01NS111745 · NINDS · COLD SPRING HARBOR LABORATORY · PI Hiroyasu Furukawa · 2019 to 2026
$4.2M
NIMH NIH HHS R01 MH085926NINDS NIH HHS R01 NS111745
6 · The paper itself

Abstract

Ion-channel activity reflects a combination of open probability and unitary conductance

Indexed as

Ion Channel GatingNeurosteroidsReceptors, N-Methyl-D-AspartateAllosteric RegulationAnimalsBinding SitesCryoelectron MicroscopyHEK293 CellsHumansHydroxycholesterolsModels, MolecularPregnenoloneProtein BindingProtein SubunitsHydroxycholesterolsNeurosteroidsNR2B NMDA receptorPregnenolonepregnenolone sulfateProtein SubunitsReceptors, N-Methyl-D-Aspartate

Identifiers

PMID41162707
PMCPMC12951714

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.