Evidence map›Paper›PMID 41162706›Full record

ArticleNature2026

Multiple LDLR family members act as entry receptors for yellow fever virus.

Zhenlu Chong, Sean Hui, Xueer Qiu, Sathvik Palakurty, Alan Sariol, Tomasz Kaszuba, Michael N Nguyen, Pengfei Li, Saravanan Raju, Paige D Hall and 11 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Zhenlu ChongDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Sean HuiDepartment of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-9870-6823
Xueer QiuDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Sathvik PalakurtyDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Alan SariolDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-3127-0543
Tomasz KaszubaDepartment of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA.
Michael N NguyenDepartment of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-4184-7078
Pengfei LiDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Saravanan RajuDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Paige D HallDepartment of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-2799-4506
Christopher A NelsonDepartment of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0001-8730-4768
Israel Baltazar-PerezDepartment of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA.
David A PriceDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Paul W RothlaufDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-0941-4467
James E CroweDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-0049-1079
Sean P J WhelanDepartment of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0003-1564-8590
Daisy W LeungDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-7189-9557
Gaya K AmarasingheDepartment of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-0418-9707
Adam L BaileyDepartment of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Daved H FremontDepartment of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-8544-2689
Michael S DiamondDepartment of Medicine, Washington University School of Medicine, St Louis, MO, USA. mdiamond@wustl.edu.ORCID 0000-0002-8791-3165

Funding

Project 5: mAb Development Flaviviruses and AlphavirusesU19AI181960 · NIAID · WASHINGTON UNIVERSITY · PI GOSS, CHARLES · 2024 to 2024
$46.7M
ANTIBODY-BASED PROTECTION AGAINST FLAVIVIRUSESU01AI073755 · NIAID · WASHINGTON UNIVERSITY · PI James E Crowe, Michael S Diamond · 2024 to 2026
$3.3M
NIAID NIH HHS U01 AI073755NIAID NIH HHS U19 AI181960Vir Biotechnology, Bavarian Nordic and Moderna.
6 · The paper itself

Abstract

Infection by yellow fever virus (YFV), the prototype Orthoflavivirus, induces a febrile syndrome in humans that can progress to liver failure, haemorrhage and death

Indexed as

Receptors, LDLReceptors, VirusVirus InternalizationYellow FeverYellow fever virusAnimalsCRISPR-Cas SystemsFemaleHEK293 CellsHepatocytesHumansLow Density Lipoprotein Receptor-Related Protein-1MaleMiceProtein DomainsViral Envelope ProteinsLow Density Lipoprotein Receptor-Related Protein-1Receptors, LDLReceptors, VirusViral Envelope ProteinsVLDL receptor

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.