Evidence map›Paper›PMID 41162705›Full record

ArticleNature2025

Origins of chromosome instability unveiled by coupled imaging and genomics.

Marco Raffaele Cosenza, Alice Gaiatto, Büşra Erarslan Uysal, Álvaro Andrades, Nina Luisa Sautter, Marina Simunovic, Michael Adrian Jendrusch, Sonia Zumalave, Tobias Rausch, Aliaksandr Halavatyi and 10 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. It's a kind of MAGIC: uncovering the origins of chromosomal instability.Signal transduction and targeted therapy · 2026
    Article
  13. Review
  14. Organoids glimpse: the nexus for diverse tumor heterogeneity.Frontiers in cell and developmental biology · 2026
    Review
  15. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Marco Raffaele CosenzaGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Alice GaiattoGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Büşra Erarslan UysalGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Álvaro AndradesGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Nina Luisa SautterGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.ORCID 0009-0005-5578-9840
Marina SimunovicGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.ORCID 0000-0002-7635-250X
Michael Adrian JendruschGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.ORCID 0000-0003-2385-6103
Sonia ZumalaveEuropean Bioinformatics Institute (EMBL-EBI), Hinxton, UK.ORCID 0000-0002-2108-1861
Tobias RauschGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.ORCID 0000-0001-5773-5620
Aliaksandr HalavatyiAdvanced Light Microscopy Core Facility, EMBL, Heidelberg, Germany.
Eva-Maria GeissenData Science Centre, EMBL, Heidelberg, Germany.
Joshua Lucas EigenmannGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.ORCID 0009-0007-5046-0661
Thomas WeberGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Patrick HasenfeldGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.ORCID 0000-0003-2319-2482
Eva BenitoGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Catherine StoberGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.
Isidro Cortes-CirianoEuropean Bioinformatics Institute (EMBL-EBI), Hinxton, UK.ORCID 0000-0002-2036-494X
Andreas E KulozikMolecular Medicine Partnership Unit (MMPU), EMBL, University of Heidelberg, Heidelberg, Germany.ORCID 0000-0003-1953-0848
Rainer PepperkokAdvanced Light Microscopy Core Facility, EMBL, Heidelberg, Germany.
Jan O KorbelGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. Jan.Korbel@embl.de.ORCID 0000-0002-2798-3794

Funding

ERC ConsolidatorEuropean Research Council
6 · The paper itself

Abstract

Somatic chromosome instability results in widespread structural and numerical chromosomal abnormalities (CAs) during cancer evolution

Indexed as

Chromosomal InstabilityGenomicsCell LineChromosome AberrationsDNA Breaks, Double-StrandedHumansMachine LearningMutationMutation RateSingle-Cell AnalysisTumor Suppressor Protein p53Tumor Suppressor Protein p53

Identifiers

PMID41162705
PMCPMC12695650

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.