ArticleNature2025
Multi-omic profiling reveals age-related immune dynamics in healthy adults.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 61 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inflammatory Aging-Driven Immune Axis Imbalance and the Mechanisms of Chronicity in Elderly Atopic Dermatitis: A Systematic Review and Meta-Analysis.Immunity, inflammation and disease · 2026Pooled it
- Aging-associated SATB1 deficiency remodels 3D genome architecture and transcriptional programs in naive CD4Science advances · 2026Article
- Rheumatoid factor production is genetically and molecularly distinct from rheumatoid arthritis.The Journal of clinical investigation · 2026Article
- Immune Cell-Stratified Regulatory Contexts Associated With BMI-Related Multi-System Disease Risk: A Cell-Stratified Mendelian Randomization Study Using Single-Cell eQTL Data.Diabetes, obesity & metabolism · 2026Article
- Pervasive tissue specificity of driver genes revealed by mutational analysis of 265 cancer types.iScience · 2026Article
- The immunology behind inflammaging-causes, sources, and mechanisms.The Journal of allergy and clinical immunology · 2026Review
- Longitudinal alignments and syntheses of multimodal clinical data for personalized medicine with the PULSE framework.Nature computational science · 2026Article
- Epigenetic regulation of B cell tolerance and dysfunction in autoimmune disease.Nature reviews. Immunology · 2026Review
- Sex-specific trajectories of nonlinear immune aging at single-cell level.Nature communications · 2026Article
- Integrative evidence-knowledge marker selection enhances LLM-based cell type annotation in single-cell RNA-seq analysis.BioData mining · 2026Article
- Multi-Omics Comes of Age: Immune Profiling of Human Aging.Immunology and cell biology · 2026Article
- The Role of CD4 T Cell Repertoire and Immune Memory Mechanisms in Vaccination and Infection Immunity.Immunological reviews · 2026Review
- Renaissance of antiviral CD8Nature reviews. Immunology · 2026Review
- IDEAL-Age: an interpretable deep learning framework for single-cell resolution profiling of immunological aging.Genome biology · 2026Article
- [Age-Related Changes in the Oral Microbiota].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Post-vaccination expansion of extrafollicular Th10 and regulatory Tfr cells distinguishes strong from weak influenza vaccine responses in older adults.medRxiv : the preprint server for health sciences · 2026Article
- What Do We Know About Immune System Aging from Human and Animal Studies?International journal of molecular sciences · 2026Review
- Biological aging clocks in health and disease.Nature medicine · 2026Review
- Article
- Accelerated Epigenetic and Inflammatory Aging and Intrinsic Capacity.JAMA network open · 2026Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
- Update of
Authors and funding
57 authors.
Qiuyu Gong *Allen Institute for Immunology, Seattle, WA, USA.ORCID 0009-0006-3885-0862
Mehul Sharma *Allen Institute for Immunology, Seattle, WA, USA.
Marla C GlassAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0003-3763-0842
Emma L KuanAllen Institute for Immunology, Seattle, WA, USA.
Aishwarya ChanderAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0002-0459-7583
Mansi SinghAllen Institute for Immunology, Seattle, WA, USA.
Lucas T GraybuckAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0002-8814-6818
Zachary J ThomsonAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0002-3861-9998
Christian M LaFranceAllen Institute for Immunology, Seattle, WA, USA.
Samir Rachid ZaimAllen Institute for Immunology, Seattle, WA, USA.ORCID 0009-0007-9256-2324
Tao PengAllen Institute for Immunology, Seattle, WA, USA.
Lauren Y OkadaAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0002-5691-3373
Palak C GengeAllen Institute for Immunology, Seattle, WA, USA.
Katherine E HendersonAllen Institute for Immunology, Seattle, WA, USA.
Elisabeth M DornischAllen Institute for Immunology, Seattle, WA, USA.
Erik D LaytonAllen Institute for Immunology, Seattle, WA, USA.
Peter J WittigAllen Institute for Immunology, Seattle, WA, USA.
Alexander T HeubeckAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0002-9312-4090
Nelson M MukukaAllen Institute for Immunology, Seattle, WA, USA.
Julian ReadingAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0002-8533-3992
Garrett StrawnAllen Institute for Immunology, Seattle, WA, USA.
Teminijesu Titus-AdewunmiAllen Institute for Immunology, Seattle, WA, USA.
Kathleen AbadieAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0003-2021-7365
Charles R RollAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0002-0726-2076
Veronica HernandezAllen Institute for Immunology, Seattle, WA, USA.
Vaishnavi ParthasarathyAllen Institute for Immunology, Seattle, WA, USA.
Tyanna J StuckeyAllen Institute for Immunology, Seattle, WA, USA.
Blessing MusgroveAllen Institute for Immunology, Seattle, WA, USA.
Elliott SwansonAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0002-0351-6446
Cara LordAllen Institute for Immunology, Seattle, WA, USA.
Morgan D A WeissAllen Institute for Immunology, Seattle, WA, USA.
Cole G PhalenAllen Institute for Immunology, Seattle, WA, USA.
Regina R MetteyAllen Institute for Immunology, Seattle, WA, USA.
Kevin J LeeAllen Institute for Immunology, Seattle, WA, USA.
John B JohannesonAllen Institute for Immunology, Seattle, WA, USA.ORCID 0009-0002-7612-1290
Erin K KaweloAllen Institute for Immunology, Seattle, WA, USA.
Jessica GarberAllen Institute for Immunology, Seattle, WA, USA.
Upaasana KrishnanAllen Institute for Immunology, Seattle, WA, USA.
Megan SmithmyerCenter for Interventional Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.
E John WherryDepartment of Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Laura A VellaInstitute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Sarah E HenricksonInstitute for Immunology and Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Mackenzie S KoppAllen Institute for Immunology, Seattle, WA, USA.
Adam K SavageAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0003-1913-5485
Lynne A BeckerAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0003-1541-4655
Paul MeijerAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0001-5535-0399
Ernest M CoffeyAllen Institute for Immunology, Seattle, WA, USA.
Jorg J GoronzyDivision of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Mikael SigvardssonAllen Institute for Immunology, Seattle, WA, USA.
Cate SpeakeCenter for Interventional Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.ORCID 0000-0003-1480-4272
Thomas F BumolAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0003-4319-1006
Ananda W GoldrathAllen Institute for Immunology, Seattle, WA, USA.
Troy R TorgersonAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0003-3489-5036
Xiao-Jun LiAllen Institute for Immunology, Seattle, WA, USA.ORCID 0000-0003-0832-9479
Peter J SkeneAllen Institute for Immunology, Seattle, WA, USA. peter.skene@alleninstitute.org.ORCID 0000-0001-8965-5326
Jane H BucknerCenter for Translational Immunology, Benaroya Research Institute at Virginia Mason, Seattle, WA, USA.ORCID 0000-0002-9005-1885
Claire E GustafsonAllen Institute for Immunology, Seattle, WA, USA. claire.gustafson@alleninstitute.org.ORCID 0000-0002-1437-6709
Funding
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3MDysregulation of Naïve T cell Quiescence during AgingK01AG068373 · NIA · STANFORD UNIVERSITY · PI GUSTAFSON, CLAIRE · 2020 to 2024
$631kNIA NIH HHS K01 AG068373NIEHS NIH HHS P30 ES013508
Abstract
The generation and maintenance of immunity is a dynamic process that is dependent on age
Indexed as
AgingProteomicsAdultAgedAged, 80 and overB-LymphocytesFemaleHealthy VolunteersHumansImmunologic MemoryInfluenza, HumanInfluenza VaccinesLongitudinal StudiesMaleMemory T CellsMiddle AgedInfluenza Vaccines
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.