Evidence map›Paper›PMID 41162703›Full record

ArticleNature2025

Thiorphan reprograms neurons to promote functional recovery after spinal cord injury.

E A van Niekerk, C Marques de Freria, B O Mancarci, K Groeniger, D Kulinich, T Riley, R Kawaguchi, S Okawa, T Vokes, E S Rosenzweig and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Transcriptomics Insights into Spinal Cord Injury for Therapy Development.International journal of molecular sciences · 2026
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

E A van NiekerkDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA. evanniekerk@health.ucsd.edu.ORCID 0000-0001-5233-1432
C Marques de FreriaDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
B O MancarciDepartment of Psychiatry, Michael Smith Laboratories, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-1452-0889
K GroenigerDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
D KulinichDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
T RileyDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
R KawaguchiDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-2489-4825
S OkawaVascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
T VokesDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
E S RosenzweigDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-0370-9643
E SinopoulouDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
M J CastleDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA.
R HuieBrain and Spinal Injury Center, University of California, San Francisco, CA, USA.
A R FergusonBrain and Spinal Injury Center, University of California, San Francisco, CA, USA.ORCID 0000-0001-7102-1608
N Kfoury-BeaumontDepartment of Neurological Surgery, University of California San Diego, San Diego, CA, USA.ORCID 0000-0001-6693-2976
A KhalessiDepartment of Neurological Surgery, University of California San Diego, San Diego, CA, USA.
P PavlidisDepartment of Psychiatry, Michael Smith Laboratories, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.ORCID 0000-0002-0426-5028
M H TuszynskiDepartment of Neurosciences, University of California San Diego, La Jolla, CA, USA. mtuszynski@ucsd.edu.ORCID 0000-0003-4182-1481

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
The Primate Corticospinal Connectome and Transcriptome - SupplementR01NS104442 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUSZYNSKI, MARK H. · 2017 to 2025
$5.7M
Embryonic Stem Cell Therapy after Cervical Contusion SCI in NHPsR01NS130033 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JACQUELINE C BRESNAHAN, Michael S Beattie · 2023 to 2026
$2.6M
NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS104442NINDS NIH HHS R01 NS130033RRD VA I50 RX001706
6 · The paper itself

Abstract

We previously identified an embryonic shift in the corticospinal motor neuronal transcriptome after spinal cord injury associated with successful axonal regeneration

Indexed as

Cellular ReprogrammingNeuronsRecovery of FunctionSpinal Cord InjuriesAnimalsCells, CulturedFemaleHumansMaleMiceMiddle AgedMotor CortexNerve RegenerationNeural Stem CellsNeuritesNeuronal Outgrowth

Identifiers

PMID41162703
PMCPMC12695623

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.