Evidence map›Paper›PMID 41162699›Full record

ArticleNature2025

Nanobody-based recombinant antivenom for cobra, mamba and rinkhals bites.

Shirin Ahmadi, Nick J Burlet, Melisa Benard-Valle, Alid Guadarrama-Martínez, Samuel Kerwin, Iara A Cardoso, Amy E Marriott, Rebecca J Edge, Edouard Crittenden, Edgar Neri-Castro and 23 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Trial
  2. Multiobjective VScience advances · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Novel antivenoms bite back.Nature biotechnology · 2026
    Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. 2025: research in review.Nature biotechnology · 2025
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Shirin Ahmadi *Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Nick J Burlet *Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0009-0002-5099-3971
Melisa Benard-ValleDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0002-0042-6592
Alid Guadarrama-MartínezDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, México.ORCID 0009-0007-6378-0859
Samuel KerwinDepartment of Biological Sciences, University of Northern Colorado, Greeley, CO, USA.
Iara A CardosoCentre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.ORCID 0000-0002-0288-4706
Amy E MarriottDepartment of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Rebecca J EdgeDepartment of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Edouard CrittendenCentre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.ORCID 0000-0003-1676-5457
Edgar Neri-CastroDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, México.
Monica L Fernandez-QuinteroDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Giang T T NguyenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0002-3536-9903
Carol O'BrienDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Yessica WoutersDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Konstantinos KalogeropoulosDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0003-3907-9281
Suthimon ThumtechoDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0002-8853-6568
Tasja Wainani EbersoleDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Camilla Holst DahlDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Emily U Glegg-SørensenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Tom JansenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0001-8006-8627
Kim BoddumSophion Bioscience, Ballerup, Denmark.ORCID 0000-0002-1588-9055
Evangelia ManousakiDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Esperanza Rivera-de-TorreDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0002-0272-6150
Andrew B WardDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.ORCID 0000-0001-7153-3769
J Preben MorthDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID 0000-0003-4077-0192
Alejandro AlagónDepartamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, México.ORCID 0000-0003-1721-3726
Stephen P MackessyDepartment of Biological Sciences, University of Northern Colorado, Greeley, CO, USA.ORCID 0000-0003-4515-2545
Stuart AinsworthDepartment of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Stefanie K MenziesBiomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.ORCID 0000-0002-9273-9296
Nicholas R CasewellCentre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.ORCID 0000-0002-8035-4719
Timothy P JenkinsDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. tpaje@dtu.dk.ORCID 0000-0003-2979-5663
Anne LjungarsDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. aellj@dtu.dk.ORCID 0000-0002-2158-0601
Andreas H LaustsenDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. ahola@bio.dtu.dk.ORCID 0000-0001-6918-5574

Funding

Wellcome Trust
6 · The paper itself

Abstract

Each year, snakebite envenoming claims thousands of lives and causes severe injury to victims across sub-Saharan Africa, many of whom depend on antivenoms derived from animal plasma as their sole treatment option

Indexed as

AntiveninsSingle-Domain AntibodiesSnake BitesAnimalsAntibodies, NeutralizingCamelidaeCamelids, New WorldElapid VenomsFemaleHumansMaleMiceNeutralization TestsPeptide LibraryRecombinant ProteinsAntibodies, NeutralizingAntiveninsElapid VenomsPeptide LibraryRecombinant ProteinsSingle-Domain Antibodies

Identifiers

PMID41162699
PMCPMC12629983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.