ArticleNature2025
Evidence for improved DNA repair in the long-lived bowhead whale.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Advancing aging biomarkers and intervention discovery at the TimePie Longevity Forum.Nature aging · 2026Article
- Article
- Somatic mutations and single-nucleus transcriptomics reveal uniquely human properties of neuronal aging.bioRxiv : the preprint server for biology · 2026Article
- Evolutionary genetics of ageing.Nature reviews. Genetics · 2026Review
- Dietary restriction is evolutionarily conserved on the phenotypic and mechanistic level.EMBO reports · 2026Article
- Rethinking the origins and functions of adaptive immunity.Trends in immunology · 2026Review
- Could mending damaged DNA prolong life?Nature · 2026Article
- A Primate-Specific lncRNA LINC01021 Contributes to Cellular and Organismal Aging via DAZAP1-Dependent Destabilization of RBMX.Aging cell · 2026Article
- Article
- Evolution of the highest fidelity DNA replication systems.bioRxiv : the preprint server for biology · 2026Article
- RNA imbalance as a hallmark of cellular ageing.Nature cell biology · 2026Review
- Insights into a long life without cancer: The case of the bowhead whale.Molecular oncology · 2026Review
- What sets the mutation rate of a cell type in an animal species?PLoS biology · 2026Article
- Article
- Suppression rather than activation of the integrated stress response (GCN2-ATF4) pathway extends lifespan in the fly.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Replacement-Based Ageing Interventions for Systemic Rejuvenation: Shaping Longevity Science and Clinical Directions.Aging cell · 2026Article
- Article
- Organelle resilience as a comparative blueprint for longevity.EMBO molecular medicine · 2026Review
- Chromatin Remodeling, DNA Double-Strand Break Repair, and Human Disease: How a Breakup Changes You.Biomolecules · 2026Review
- Molecular evolution of animal aging.The EMBO journal · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
55 authors.
Denis Firsanov *Department of Biology, University of Rochester, Rochester, NY, USA.
Max Zacher *Department of Biology, University of Rochester, Rochester, NY, USA.ORCID 0000-0003-0377-7221
Xiao TianDepartment of Biology, University of Rochester, Rochester, NY, USA.
Todd L SformoNorth Slope Borough Department of Wildlife Management, Utqiaġvik (Barrow), AK, USA.ORCID 0000-0003-4833-2007
Yang ZhaoDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID 0000-0002-8703-3678
Gregory TomblineDepartment of Biology, University of Rochester, Rochester, NY, USA.
J Yuyang LuDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID 0000-0003-3170-5655
Zhizhong ZhengDepartment of Biology, University of Rochester, Rochester, NY, USA.
Luigi PerelliDepartment of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-7320-8193
Enrico GurreriDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-7752-4641
Li ZhangDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-7750-6427
Jing GuoDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID 0000-0003-4154-1885
Anatoly KorotkovDepartment of Biology, University of Rochester, Rochester, NY, USA.
Valentin VolobaevDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID 0000-0001-7355-9882
Seyed Ali BiashadDepartment of Biology, University of Rochester, Rochester, NY, USA.
Zhihui ZhangDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID 0000-0003-0635-6297
Johanna HeidDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0001-7760-5217
Alexander Y MaslovDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0001-5402-8891
Shixiang SunDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.ORCID 0000-0001-5499-2963
Zhuoer WuDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID 0009-0000-4694-6668
Jonathan GigasDepartment of Biology, University of Rochester, Rochester, NY, USA.
Eric C HillpotDepartment of Biology, University of Rochester, Rochester, NY, USA.
John C MartinezDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID 0000-0003-0040-8519
Minseon LeeDepartment of Biology, University of Rochester, Rochester, NY, USA.
Alyssa WilliamsDepartment of Biology, University of Rochester, Rochester, NY, USA.
Abbey GilmanDepartment of Biology, University of Rochester, Rochester, NY, USA.
Nicholas HamiltonDepartment of Biology, University of Rochester, Rochester, NY, USA.
Ekaterina StrelkovaDepartment of Biology, University of Rochester, Rochester, NY, USA.
Ena HaseljicDepartment of Biology, University of Rochester, Rochester, NY, USA.
Avnee PatelDepartment of Biology, University of Rochester, Rochester, NY, USA.
Maggie E StraightDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID 0000-0001-7916-0282
Nalani MillerDepartment of Biology, University of Rochester, Rochester, NY, USA.
Julia AblaevaDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID 0000-0002-0938-2629
Lok Ming TamDepartment of Biology, University of Rochester, Rochester, NY, USA.ORCID 0000-0002-6211-6880
Chloé CoudercDepartment of Biology, University of Rochester, Rochester, NY, USA.
Michael R HoopmannInstitute for Systems Biology, Seattle, WA, USA.ORCID 0000-0001-7029-7792
Robert L MoritzInstitute for Systems Biology, Seattle, WA, USA.ORCID 0000-0002-3216-9447
Shingo FujiiCancer Research Center of Marseille, Department of Genome Integrity, CNRS UMR7258, Inserm U1068, Institut Paoli-Calmettes, Aix Marseille University, Marseille, France.ORCID 0000-0002-5800-7235
Amandine PelletierCancer Research Center of Marseille, Department of Genome Integrity, CNRS UMR7258, Inserm U1068, Institut Paoli-Calmettes, Aix Marseille University, Marseille, France.
Dan J HaymanSchool of Biosciences, University of Sheffield, Sheffield, UK.ORCID 0000-0001-9125-1945
Hongrui LiuDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-6274-5951
Yuxuan CaiDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Anthony K L LeungDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0001-5569-4036
Zhengdong ZhangDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA.
C Bradley NelsonHuntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.ORCID 0009-0007-8775-1809
Lisa M AbegglenDepartment of Pediatrics and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0003-3607-3001
Joshua D SchiffmanDepartment of Pediatrics and Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.ORCID 0000-0002-6968-7694
Vadim N GladyshevDivision of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0372-7016
Carlo C MaleyArizona Cancer Evolution Center, Biodesign Institute, Arizona State University, Tempe, AZ, USA.ORCID 0000-0002-0745-7076
Mauro ModestiCancer Research Center of Marseille, Department of Genome Integrity, CNRS UMR7258, Inserm U1068, Institut Paoli-Calmettes, Aix Marseille University, Marseille, France.ORCID 0000-0002-4964-331X
Giannicola GenoveseDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-1392-9954
Mirre J P SimonsSchool of Biosciences, University of Sheffield, Sheffield, UK.ORCID 0000-0001-7406-7708
Jan VijgDepartment of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA. jan.vijg@einsteinmed.edu.ORCID 0000-0002-8457-9595
Andrei SeluanovDepartment of Biology, University of Rochester, Rochester, NY, USA. andrei.seluanov@rochester.edu.
Vera GorbunovaDepartment of Biology, University of Rochester, Rochester, NY, USA. vera.gorbunova@rochester.edu.ORCID 0000-0001-8979-0333
Funding
The role of hyaluronan in longevity and cancer resistance of longest-lived rodentP01AG047200 · NIA · UNIVERSITY OF ROCHESTER · PI JAN VIJG · 2014 to 2026
$36.9MSomatic Activation of Retrotransposition: A New Molecular Mechanism of Aging?P01AG051449 · NIA · BROWN UNIVERSITY · PI Jef D BOEKE · 2016 to 2026
$30.4MValidation and characterization of the identified variants associated with human longevity in mouse modelsU19AG056278 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Zhengdong Zhang · 2017 to 2026
$24.5MIdentifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategiesUH3AG064704 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI PERLS, THOMAS T, SEBASTIANI, PAOLA · 2022 to 2025
$14.7MIdentifying protective omics profiles in centenarians and translating these into preventive and therapeutic strategiesUH2AG064704 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI PERLS, THOMAS T, SEBASTIANI, PAOLA · 2019 to 2021
$9.4MThe Role of the Microbiome in Cancer Suppression and Susceptibility Across SpeciesU54CA217376 · NCI · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI MALEY, CARLO · 2018 to 2022
$8.6MModeling Neoplastic Progression in Barrett's Esophagus - Renewal -2R01CA140657 · NCI · WISTAR INSTITUTE · PI Carlo Maley · 2009 to 2026
$5.0MRegulation of epigenome stability by SIRT6 during aging. Supplement: Does centenarian variant of SIRT6 or bowhead whale SIRT6 confer protection from Alzheimer's disease?R37AG046320 · NIA · UNIVERSITY OF ROCHESTER · PI Andrei Seluanov · 2019 to 2026
$4.7MRole of ADP-Ribosylation in Stress Granules-Equipment SupplementR01GM104135 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Anthony K L Leung · 2015 to 2026
$4.2MIntegrative Omics to enhance therapeutics development for healthy agingUH3AG064706 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI MILLER, RICHARD A, SCHORK, NICHOLAS JOSEPH · 2021 to 2024
$3.3MInvestigation of the role of epithelial-mesenchymal plasticity in renal cell carcinomaR01CA258226 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI GENOVESE, GIANNICOLA · 2021 to 2025
$2.9MElucidating T Cell Ferroptosis in Renal Medullary Carcinoma: 3D Genome Architecture Rewiring and Therapeutic AlleviationR01CA285454 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Wenbo Li, Pavlos Msaouel · 2024 to 2026
$2.0MNCI NIH HHS R01 CA140657NCI NIH HHS R01 CA258226NCI NIH HHS R01 CA285454NCI NIH HHS R37 CA288448NCI NIH HHS U54 CA217376NIA NIH HHS P01 AG047200NIA NIH HHS P01 AG051449NIA NIH HHS R01 AG046320NIA NIH HHS R37 AG046320NIA NIH HHS U19 AG056278NIA NIH HHS UH2 AG064704NIA NIH HHS UH2 AG064706NIA NIH HHS UH3 AG064704NIA NIH HHS UH3 AG064706NIGMS NIH HHS R01 GM104135NINDS NIH HHS R03 NS145168Wellcome Trust
Abstract
At more than 200 years, the maximum lifespan of the bowhead whale exceeds that of all other mammals. The bowhead is also the second-largest animal on Earth
Indexed as
Bowhead WhaleDNA RepairLongevityAnimalsCell Transformation, NeoplasticDNA Breaks, Double-StrandedDNA End-Joining RepairDrosophila melanogasterFemaleFibroblastsHumansMaleMutation RateRecombinational DNA RepairRNA-Binding ProteinsRNA-Binding Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.