Evidence map›Paper›PMID 41162686›Full record

ArticleNature biomedical engineering2026

Iontronic tip-sensing guidewires.

Fangyi Guan, Ningning Bai, Jia Song, Nian Zhang, Jiyu Li, Yizhou Jiang, Zhiliang Han, Hanxin Wang, Junli Shi, Xi Xia and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fangyi Guan *Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China.
Ningning Bai *Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China.
Jia SongDepartment of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0001-8816-9115
Nian ZhangDepartment of Modern Mechanics, University of Science and Technology of China, Hefei, China.
Jiyu LiDepartment of Modern Mechanics, University of Science and Technology of China, Hefei, China.
Yizhou JiangState Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.ORCID http://orcid.org/0000-0002-5778-8455
Zhiliang HanState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, China.
Hanxin WangDepartment of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0001-9408-1750
Junli ShiDepartment of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China.ORCID http://orcid.org/0000-0002-6053-5766
Xi XiaDepartment of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China.
Xudong ChenDepartment of Interventional Radiology, Shenzhen People's Hospital, Shenzhen, China.
Chuan Fei GuoDepartment of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen, China. guocf@sustech.edu.cn.ORCID http://orcid.org/0000-0003-4513-3117
Liu WangDepartment of Modern Mechanics, University of Science and Technology of China, Hefei, China. wangliu05@ustc.edu.cn.ORCID http://orcid.org/0000-0001-7014-9976

Funding

National Natural Science Foundation of China (National Science Foundation of China) 12272369National Natural Science Foundation of China (National Science Foundation of China) T2225017
6 · The paper itself

Abstract

Plaque accumulation in coronary arteries causes stenoses, reducing blood flow and increasing the risk of cardiovascular disorders such as heart attacks. To assess the physiological impact of blood pressure across a stenosis, commercial pressure guidewires measure the fractional flow reserve using optical, piezoresistive or piezoelectric sensors, which suffer from brittleness, limited manoeuvrability and high costs. Here we report an iontronic tip-sensing guidewire (ITG) that integrates a thin iontronic tip sensor in a commercial workhorse guidewire via iontronic-based signal transmission, leveraging the ionic nature of human tissues. Intravascular pressure changes induce a capacitance difference at the interface of the metal and ionic gel of the ITG, allowing detection of subtle pressure changes in blood flow, substantially outperforming commercial guidewires. The ITG is free of embedded conductive leads needed in other pressure guidewires to ensure an ideal torque ratio for high manoeuvrability, and we validated its effectiveness and sensitivity in rabbit, goat and pig models in vivo. The compatibility of the ITG with commercial horsework guidewires will upgrade the design of interventional medical devices.

Indexed as

Blood PressureEquipment DesignAnimalsGoatsHumansRabbitsSwine

Identifiers

PMID41162686

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.