Evidence map›Paper›PMID 41162649›Full record

ArticleNpj viruses2025

Estimating the decay of protective antibodies induced by SARS-CoV-2 mRNA vaccination and hybrid immunity.

McKenna D Roe, Si'Ana A Coggins, Emily S Darcey, Emilie Goguet, Hannah Haines-Hull, Dominic Esposito, Cara H Olsen, Simon D Pollett, Edward Mitre, Eric D Laing

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Npj viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

McKenna D RoeDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Si'Ana A CogginsDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Emily S DarceyDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Emilie GoguetDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Hannah Haines-HullDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Dominic EspositoProtein Expression Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Cara H OlsenDepartment of Preventive Medicine and Biostatistics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
Simon D PollettHenry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD, USA.
Edward MitreDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA.
Eric D LaingDepartment of Microbiology and Immunology, Uniformed Services University, Bethesda, MD, USA. Eric.laing@usuhs.edu.

Funding

Defense Health Agency HU00011920111Defense Health Program HU00012020067Immunization Healthcare Branch HU00012120104
6 · The paper itself

Abstract

Starting in 2020, we quantified anti-wildtype SARS-CoV-2 spike sera IgG at monthly intervals from generally healthy adults after various doses of mRNA-based COVID-19 vaccination and in the context of hybrid immunity. Confirmed post-vaccination infections and subclinical infections identified by longitudinal serology were removed from vaccine-only analyses. Over 400 days, the two-dose vaccine-alone antibody response decayed at a half-life (t

Identifiers

PMID41162649
PMCPMC12572167

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.