ArticleNature neuroscience2025
Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Effect of Intranasal Dexmedetomidine on the Night Before Surgery for Postoperative Delirium in Older Patients Undergoing Total Hip or Knee Arthroplasty: A Randomized Clinical Trial.Drug design, development and therapy · 2026Trial
- A conversation on human brain clearance.Nature communications · 2026Article
- Non-invasive characterization of perivascular subarachnoid spaces.Nature communications · 2026Article
- Inhibitory Decay and Supercritical Brain Dynamics During Sleep Deprivation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Sleep-like slow waves during resting-state: A promising EEG biomarker of amyloid and neurodegeneration in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A hypothalamic-brainstem activity sequence underlies arousal fluctuations during daytime drowsiness.bioRxiv : the preprint server for biology · 2026Article
- Spatiotemporally dynamic noradrenergic regulation of cortical networks.bioRxiv : the preprint server for biology · 2026Article
- Quantitative assessment of flow between cerebrospinal and interstitial fluid compartments in humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Stretch and flow at the gliovascular interface: High-fidelity modeling of astrocyte endfeet.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Fatigue-related factors and perceived team functioning in United States Navy Surface Forces.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Exploring the differences in neural oscillation mechanisms before and after sleep deprivation.Frontiers in neuroscience · 2026Article
- Modulation of neurofluid fluctuation frequency by baseline carbon dioxide in awake humans: the role of the autonomic nervous system.Frontiers in physiology · 2026Article
- Simultaneous real-time imaging of upper cervical cerebrospinal fluid and vascular dynamics using ultrafast inflow-weighted EPI.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Bedtime Procrastination and Attention as Serial Mediators Between Premenstrual Syndrome and Test Anxiety in Nursing College Students: A Multicenter Cross-Sectional Study.Psychology research and behavior management · 2026Article
- Review
Corrections and comments
- Update of
Authors and funding
6 authors.
Funding
Abstract
Sleep deprivation rapidly disrupts cognitive function and in the long term contributes to neurological disease. Why sleep deprivation has such profound effects on cognition is not well understood. Here we use simultaneous fast fMRI-EEG to test how sleep deprivation modulates cognitive, neural and fluid dynamics in the human brain. We demonstrate that attentional failures during wakefulness after sleep deprivation are tightly orchestrated in a series of brain-body changes, including neuronal shifts, pupil constriction and cerebrospinal fluid (CSF) flow pulsations, pointing to a coupled system of fluid dynamics and neuromodulatory state. CSF flow and hemodynamics are coupled to attentional function within the awake state, with CSF pulsations following attentional impairment. The timing of these dynamics is consistent with a vascular mechanism regulated by neuromodulatory state. The attentional costs of sleep deprivation may thus reflect an irrepressible need for rest periods driven by a central neuromodulatory system that regulates both neuronal and fluid physiology.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.