ArticleScientific reports2025
Interplay between key metabolic hormones, metabolic factors, renal function, and heart rate variability in humans with obesity.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
Abstract
This study aimed to provide the first integrative assessment of clinical, metabolic, renal, hormonal, and heart rate variability (HRV) parameters in individuals with obesity, stratified by metabolic syndrome (MetS) and insulin resistance (IR), clarifying shared and distinct mechanisms beyond prior HRV- or hormone-focused studies. Among 45 participants with obesity (BMI ≥ 25 kg/m²), 67% had IR and 42% had MetS. Both groups exhibited increased %fat, triglyceride, leptin, and resting heart rate, with decreased QUICKI and high-density lipoprotein cholesterol (HDL-C) (p < 0.05 all). Frequency-domain HRV (VLF and LF ms²) and overall variability (SDNN) were significantly decreased in the IR group (p < 0.05 all). Leptin showed significant positive correlations with obesity, IR, and creatinine clearance (p < 0.05 all). Adiponectin exhibited positive correlations with hip circumference, HDL-C, and pNN50 while HDL-C showed negative correlations with the number of MetS criteria, obesity, IR, and leptin, but positive correlations with parasympathetic HRV (SDSD and RMSSD) (p < 0.05 all), suggesting a protective role across multiple systems. Creatinine clearance and eGFR revealed positive correlations with parasympathetic HRV (HF nu) and negative correlations with sympathetic HRV (LF nu and LF/HF ratio). In conclusion, this study underscores the complex interplay between these systems, enhancing our understanding of their shared and distinct mechanisms.
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