Evidence map›Paper›PMID 41162560›Full record

ArticleScientific reports2025

The impact of decreased left ventricular ejection fraction on neutrophil extracellular trap (NET) formation measured by citrullinated histone H3 (citH_3) concentration.

Tomasz Urbanowicz, Beata Krasińska, Ievgen Spasenenko, Katarzynia Gabriel, Paulina Dziatkiewicz-Warkocz, Sebastian Mertowski, Krzysztof Bojarski, Ewelina Grywalska, Krzysztof Filipiak, Andrzej Tykarski and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tomasz UrbanowiczCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, Długa ½ Street, Poznan, 61-848, Poland. turbanowicz@ump.edu.pl.
Beata KrasińskaDepartment of Hypertensiology, Angiology and Internal Medicine, University of Medical Sciences, Długa ½ Street, Poznan, 61-848, Poland.
Ievgen SpasenenkoDepartment of Hypertensiology, Angiology and Internal Medicine, University of Medical Sciences, Długa ½ Street, Poznan, 61-848, Poland.
Katarzynia GabrielDepartment of Hypertensiology, Angiology and Internal Medicine, University of Medical Sciences, Długa ½ Street, Poznan, 61-848, Poland.
Paulina Dziatkiewicz-WarkoczDepartment of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznan, 61-701, Poland.
Sebastian MertowskiDepartment of Experimental Immunology, Medical University of Lublin, Chodźki 4a St., Lublin, 20-093, Poland.
Krzysztof BojarskiGeneral Surgery Department, SP ZOZ in Łęczna, Łęczna, 21-010, Poland.
Ewelina GrywalskaDepartment of Experimental Immunology, Medical University of Lublin, Chodźki 4a St., Lublin, 20-093, Poland.
Krzysztof FilipiakDepartment of Hypertensiology, Angiology and Internal Medicine, University of Medical Sciences, Długa ½ Street, Poznan, 61-848, Poland.
Andrzej TykarskiDepartment of Hypertensiology, Angiology and Internal Medicine, University of Medical Sciences, Długa ½ Street, Poznan, 61-848, Poland.
Zbigniew KrasińskiDepartment of Vascular, Endovascular Surgery, Angiology and Phlebology, Medical University, Poznan University of Medical Science, Długa ½ Street, Poznan, 61- 848, Poland.
Marek JemielityCardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, Długa ½ Street, Poznan, 61-848, Poland.
Lidia GilDepartment of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznan, 61-701, Poland.
Joanna Rupa-MatysekDepartment of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Poznan, 61-701, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pro-coagulative characteristics of HF patients are postulated, though no specific therapeutic targets have been proposed. A total of 88 patients (17 female, 19%) with a median age of 68 years (range, 63 - 74) and a de novo congestive HF diagnosis were enrolled in the prospective study. Co-morbidities, laboratory tests, and imaging results (echocardiography, coronary angiography) were compared to the concentration of peripheral blood citrullinated histone 3 (CitH_3), a marker of neutrophil extracellular trap (NET) formation, on admission. The analyzed population was divided into two groups based on LVEF performance: HFmrEF (42 patients, 47%) and HFrEF (46 patients, 53%), with a median (Q1-Q3) age of 68 (62-74) vs. 69 (63-74) years (p = 0.789), respectively. The significant difference in CitH_3 serum concentration between the heart failure with preserved ejection fraction (HFrmEF) group (395 pg/ml [201-482]) and the heart failure with reduced ejection fraction (HFrEF) group (1941 pg/ml [405-3376]) was noted (p = 0.019). A negative correlation was noted between LVEF and citH_3 in the analyzed group (r = -0.444, p = 0.005), and with serum NT-pro-BNP (r =  -0.435, p < 0.001). No correlation between citH_3 and NT-pro-BNP was found (r = 0.305, p = 0.939). Patients with heart failure and a decreased left ventricular ejection fraction can be characterized by increased neutrophil extracellular trap formation. The negative correlation between left ventricular characteristics and CitH_3 concentration suggested an increased pro-thrombotic state in HF patients. NETs could be considered a potential therapeutic target in HF patients to improve clinical outcomes. Further studies are required to confirm these findings.

Indexed as

Extracellular TrapsHeart FailureHistonesStroke VolumeVentricular Function, LeftAgedBiomarkersCitrullinationFemaleHumansMaleMiddle AgedNeutrophilsProspective StudiesBiomarkersHistones

Identifiers

PMID41162560
PMCPMC12572215

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.