Evidence map›Paper›PMID 41162529›Full record

ArticleScientific reports2025

A novel computational model for human macular pigment optical density and its relationship to foveal structure.

Gary P Misson, Stephen J Anderson, Richard A Armstrong, Rebekka Heitmar

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gary P MissonSchool of Optometry, College of Health and Life Sciences, Aston University, Birmingham, UK. g.misson@aston.ac.uk.ORCID http://orcid.org/0000-0001-8843-8389
Stephen J AndersonSchool of Optometry, College of Health and Life Sciences, Aston University, Birmingham, UK.ORCID http://orcid.org/0000-0002-5719-2846
Richard A ArmstrongSchool of Optometry, College of Health and Life Sciences, Aston University, Birmingham, UK.ORCID http://orcid.org/0000-0002-5046-3199
Rebekka HeitmarCentre for Vision across the Life Span (CVLS), School of Applied Sciences, University of Huddersfield, Huddersfield, UK.ORCID http://orcid.org/0000-0002-7657-1788

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macular pigment optical density (MPOD) models enhance understanding of macular xanthophyll distribution, particularly relevant to age-related macular degeneration. This study investigates an existing model and introduces a novel, more accurate and biologically relevant approach. MPOD spatial profiles of 48 eyes were obtained using dual-wavelength autofluorescence imaging, with structural data from OCT and OCT-angiography. MPOD data were analyzed using (a) an existing sum of exponential and Gaussian model (M

Indexed as

Computer SimulationFovea CentralisMacular PigmentAgedFemaleHumansMacula LuteaMacular DegenerationMaleMiddle AgedTomography, Optical CoherenceXanthophyllsMacular PigmentXanthophylls

Identifiers

PMID41162529
PMCPMC12572246

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.