Allele-specific gene expression in F1 hybrid mice reveals structural variants affecting macrophage characteristics.

Keisuke Yoshida, Toyoyuki Takada, Masafumi Muratani, Takanori Amano

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Keisuke YoshidaNext Generation Human Disease Model Research Team, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 305-0074, Japan. keisuke-yoshida@nms.ac.jp.

Toyoyuki TakadaIntegrated Bioresource Information Division, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 305-0074, Japan.

Masafumi MurataniDepartment of Genome Biology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.

Takanori AmanoNext Generation Human Disease Model Research Team, RIKEN BioResource Research Center, Tsukuba, Ibaraki, 305-0074, Japan. takanori.amano@riken.jp.

Funding

JSPS KAKENHI JP 19K06477, JP 23K05610

6 · The paper itself

Abstract

Genetic diversity underlies the foundation for variations in gene expression, resulting in diverse phenotypic traits. In this study, we investigated the effect of genetic variation on macrophage function using two genetically distinct mouse strains, C57BL/6 (B6) and Japanese Fancy Mouse 1 (JF1), which exhibit substantial genetic polymorphisms. Gene expression analysis of macrophages derived from B6, JF1, and their F1 hybrids revealed strain-specific allelic expression of immune-related and glycolytic genes, indicating significant influence of cis-regulatory variants on macrophage function. These findings highlight the role of genetic variation in shaping immune responses and metabolic pathways and provide new insights into the genetic basis of phenotypic diversity in macrophages among subspecies of mice.

Indexed as

AllelesGene Expression RegulationMacrophagesAnimalsGenetic VariationMiceMice, Inbred C57BLPhenotypeAllelic expressionInnate immunityMacrophageMouse strainStructural variation

Identifiers

PMID41162494

DOI10.1038/s41598-025-21643-w

PMCPMC12572132

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.