Evidence map›Paper›PMID 41162486›Full record

Observational studyScientific reports2025

Pain catastrophizing and its domains significantly impact rheumatoid arthritis disease activity.

Damiano Currado, Lyubomyra Kun, Francesca Saracino, Leonardo Frascà, Francesca Trunfio, Onorina Berardicurti, Erika Corberi, Annalisa Marino, Andrea Pilato, Ludovica Lamberti and 19 more

Abstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Damiano CurradoClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Lyubomyra KunRheumatology and Clinical Immunology, Department of Medicine, School of Medicine, University of Rome "Campus Bio-Medico", Rome, Italy.
Francesca SaracinoRheumatology and Clinical Immunology, Department of Medicine, School of Medicine, University of Rome "Campus Bio-Medico", Rome, Italy.
Leonardo FrascàRheumatology and Clinical Immunology, Department of Medicine, School of Medicine, University of Rome "Campus Bio-Medico", Rome, Italy.
Francesca TrunfioRheumatology and Clinical Immunology, Department of Medicine, School of Medicine, University of Rome "Campus Bio-Medico", Rome, Italy.
Onorina BerardicurtiClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. o.berardicurti@policlinicocampus.it.
Erika CorberiRheumatology and Clinical Immunology, Department of Medicine, School of Medicine, University of Rome "Campus Bio-Medico", Rome, Italy.
Annalisa MarinoClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Andrea PilatoRheumatology and Clinical Immunology, Department of Medicine, School of Medicine, University of Rome "Campus Bio-Medico", Rome, Italy.
Ludovica LambertiRheumatology and Clinical Immunology, Department of Medicine, School of Medicine, University of Rome "Campus Bio-Medico", Rome, Italy.
Marta VadaccaClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Amelia RigonClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Luisa ArcareseClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Piero RuscittiRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Ilenia PantanoRheumatology Unit, Department of Precision Medicine, University of Campania L. Vanvitelli, Caserta, Italy.
Marta VomeroRheumatology and Clinical Immunology, Department of Medicine, School of Medicine, University of Rome "Campus Bio-Medico", Rome, Italy.
Viktoriya PavlychRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Claudio Di VicoRheumatology Unit, Department of Precision Medicine, University of Campania L. Vanvitelli, Caserta, Italy.
Federica CamardaRheumatology Section, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University Hospital "P. Giaccone", Palermo, Italy.
Francesca MisceoRheumatic and Systemic Autoimmune Diseases Unit, Department of Biomedical Science and Human Oncology (DIMO), University of Bari Medical School, Bari, Italy.
Francesco De VincenzoDepartment of Human Sciences, European University of Rome, Rome, Italy.
Addolorata CorradoRheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia, Rione Biccari, Foggia, 71122, Italy.
Francesco Paolo CantatoreRheumatology Clinic, Department of Medical and Surgical Sciences, University of Foggia, Rione Biccari, Foggia, 71122, Italy.
Federico PerosaRheumatic and Systemic Autoimmune Diseases Unit, Department of Biomedical Science and Human Oncology (DIMO), University of Bari Medical School, Bari, Italy.
Giuliana GugginoRheumatology Section, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University Hospital "P. Giaccone", Palermo, Italy.
Paola CiprianiRheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.
Francesco CicciaRheumatology Unit, Department of Precision Medicine, University of Campania L. Vanvitelli, Caserta, Italy.
Roberto GiacomelliClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Luca NavariniClinical and Research Section of Rheumatology and Clinical Immunology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to evaluate the impact of pain catastrophizing (PC) on disease activity in patients with rheumatoid arthritis (RA) and to explore, in the same participants, if this association is related or not with anxiety and depression, which have been related to catastrophization in patients with chronic pain. A multi-center, observational study has been conducted on 158 RA patients from six Rheumatology Clinics. Participants were assessed using the Clinical Disease Activity Index (CDAI) and Simple Disease Activity Index (SDAI) and Disease Activity Score on 28 joints- C reactive protein (DAS28-CRP). Pain Catastrophizing, with its domains of Helplessness, Rumination and Magnification, was analyzed through Pain Catastrophizing Scale (PCS). Statistical analyses included univariable and multivariable regressions, to identify associations between disease activity and PC. Results revealed that higher PCS scores were significantly associated with increased CDAI, SDAI and DAS28-CRP values, indicating higher disease activity. Specifically, the domains of Rumination and Helplessness showed a strong correlation with disease activity, while Magnification did not. These associations persisted independently of anxiety and depression mood, as shown by multivariable regression analysis. Pain catastrophizing, particularly the domains of Rumination and Helplessness, significantly influences disease activity in RA patients, independent of mood disorders. These findings underscore the importance of addressing maladaptive cognitive perceptions of pain in the management of RA, to improve patient outcomes and facilitate disease remission.

Indexed as

Arthritis, RheumatoidCatastrophizationPainAdultAgedAnxietyDepressionFemaleHumansMaleMiddle AgedPain MeasurementSeverity of Illness IndexDisease activityPain catastrophizingRheumatoid arthritis

Identifiers

PMID41162486
PMCPMC12572140

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.